The search textbox has an autosuggest feature. When you enter three or more characters,
a list of up to 10 suggestions will popup under the textbox. Use the arrow keys
to move through the suggestions. To select a suggestion, hit the enter key. Using
the escape key closes the listbox and puts you back at the textbox. The radio buttons
allow you to toggle between having all search items start with or contain the text
you entered in the search box.
fosbretabulin tromethamine
The tromethamine salt form of prodrug fosbretabulin, a water-soluble phosphate derivative of a stilbenoid phenol derived from the African bush willow (Combretum caffrum) with antineoplastic activities. Upon administration, fosbretabulin is dephosphorylated to its active metabolite, combretastatin A4, which targets and binds to tubulin dimers and prevents microtubule polymerization, thereby resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | combretastatin A4 phosphate | |
| |||
| US brand name: | | Zybrestat | |
| |||
| Abbreviation: | | CA4P | |
| |||
| Chemical structures: | | 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl hydrogen phosphate 1,3-propanediol, 2-amino-2-(hydroxymethyl)-, compd. with 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl dihydrogen phosphate (1:1) | |
| |||
