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daniquidone
A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | batracylin | |
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| Chemical structure: | | 8-aminoisoindolo(1,2-b)quinazolin-12(10H)-one | |
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