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aprepitant
A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Emend | |
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| Code names: | | L-754030 MK-0869 ONO-7436 | |
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