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flutamide
A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Flucinom Flugerel Niftolid | |
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| US brand name: | | Eulexin | |
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| Foreign brand names: | | Apimid Chimax Drogenil Euflex Eulexine Flucinome Fluken Flulem Flutabene Flutacan Fluta-Gry Flutamex Flutamin Flutan Flutaplex Fugerel Grisetin Oncosal Profamid Prostacur Prostadirex Prostica Prostogenat Tafenil Tecnoflut Testotard | |
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| Abbreviation: | | FLUT | |
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| Code name: | | Sch 13521 | |
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| Chemical structures: | | 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 4'-nitro-3'-trifluoromethylisobutyranilide alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide | |
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