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glucarpidase
A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | carboxypeptidase-G2 | |
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| US brand name: | | Voraxaze | |
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| Abbreviations: | | CPDG2 CPG2 | |
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