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BL22 immunotoxin
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Anti-CD22 Recombinant Immunotoxin BL22 BL22 BL22 Immunotoxin [RFB4(dsFv) - PE38 RFB4(dsFv)-PE38 immunotoxin | |
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| Abbreviation: | | BL22 | |
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| Code name: | | CAT-3888 | |
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