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mechlorethamine hydrochloride
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | chloramin chlorethamine HCl chlorethamine hydrochloride chlorethazine chlorethazine hydrochloride chlormethine chlormethine hydrochloride chloromethine HCl mechlorethamine mechlorethamine HCl methylchlorethamine Mustard mustargen HCl mustargen hydrochloride Mustine NH-2 N-Lost | ||
US brand name: | Mustargen | ||
Foreign brand names: | Caryolysine Cloramin Erasol Mustine Hydrochloride Onco-Cloramin | ||
Abbreviations: | HN 2 NM | ||
Acronym: | NM | ||
Code name: | WR-147650 | ||
Chemical structures: | bis(2-chloroethyl)methylamine ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl methylbis(beta-chloroethyl)amine | ||