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mitoxantrone hydrochloride
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | dihydroxyanthracenedione dihydroxyanthracenedione dihydrochloride mitoxantrone dihydrochloride mitoxantrone HCl mitozantrone | |
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| US brand name: | | Novantrone | |
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| Foreign brand names: | | Mitroxone Neotalem Onkotrone Pralifan | |
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| Abbreviations: | | DHAD DHAQ | |
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| Code name: | | CL 232315 | |
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| Chemical structures: | | 1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone dihydroxyanthracenedione | |
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