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oprelvekin
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | adipogenesis inhibitory factor IL-11 interleukin 11 recombinant human interleukin-11 therapeutic interleukin-11 | |
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| US brand name: | | Neumega | |
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| Abbreviation: | | rhIL-11 | |
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