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hydroxyurea
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | HYD Hydroxycarbamide Hydurea | ||
US brand names: | Droxia Hydrea | ||
Foreign brand names: | Litalir Onco-Carbide Oxeron Syrea | ||
Abbreviation: | HU | ||
Code names: | SQ-1089 WR 83799 | ||