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ISIS 5132
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | c-RAF Antisense ISIS 5132/CGP69846A RAF-IK Antisense ODN | |
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| Code names: | | CGP 69846A CGP69846A ISIS-5132 | |
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