Gonococcal Isolate Surveillance Project (GISP)
The Gonococcal Isolate Surveillance Project (GISP) was established in 1986 to monitor trends in antimicrobial susceptibilities of strains of N. gonorrhoeae in the United States in order to establish a rational basis for the selection of gonococcal therapies. GISP is a collaborative project among selected sexually transmitted diseases (STD) clinics, five regional laboratories, and the Centers for Disease Control and Prevention (CDC).
In GISP, N. gonorrhoeae isolates are collected from the first 25 men with urethral gonorrhea attending STD clinics each month in approximately 28 cities in the United States. At regional laboratories, the susceptibilities of these isolates to penicillin, tetracycline, spectinomycin, ciprofloxacin, ceftriaxone, cefixime, and azithromycin are determined by agar dilution. Minimum inhibitory concentrations (MICs) are measured, and values are interpreted according to criteria recommended by the Clinical and Laboratory Standards Institute (CLSI).
Protocol
Annual Reports and Profiles
- 2010 STD Surveillance Report - Gonorrhea (overall GISP data)
- 2010 GISP Profiles (site-specific GISP data)
- GISP Profiles (2008-2010) and Annual Reports (1998-2007)
Recent Publications
- The Emerging Threat of Untreatable Gonococcal Infection. New England Journal of Medicine 2012; 366(6):485-487.
- Cephalosporin Susceptibility Among Neisseria gonorrhoeae Isolates --- United States, 2000—2010 - MMWR July 8, 2011
- Neisseria gonorrhoeae with Reduced Susceptibility to Azithromycin --- San Diego County, California, 2009 – MMWR May 13, 2011
Sentinel Sites and Regional Laboratories
Click thumbnail for larger map
* indicates Regional Laboratories
- Albuquerque, NM
- Atlanta, GA *
- Baltimore, MD
- Birmingham, AL *
- Chicago, IL
- Cleveland, OH *
- Dallas, TX
- Denver, CO
- Greensboro, NC
- Honolulu, HI
- Kansas City, MO
- Las Vegas, NV
- Los Angeles, CA
- Miami, FL
- Minneapolis, MN
- New Orleans, LA
- New York, NY
- Orange County, CA
- Oklahoma City, OK
- Philadelphia, PA
- Phoenix, AZ
- Portland, OR
- Pontiac, MI
- Richmond, VA
- San Diego, CA
- San Francisco, CA
- Seattle, WA *
- Tripler Army Medical center, Honolulu, HI
Forms & Coding Guide
- GISP Form 1: Demographic/Clinical Data
- GISP Form 2: Antimicrobial Susceptibility Testing
- GISP Form 3: Control Strain Susceptibility Testing
- Coding Guide for GISP Forms
Contact Us:
- Centers for Disease Control and Prevention
1600 Clifton Rd
Atlanta, GA 30333 - 800-CDC-INFO
(800-232-4636)
TTY: (888) 232-6348 - Contact CDC-INFO
