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Department of Health and Human Services
Centers for Disease Control and Prevention


Vaccines & Immunizations

Vaccines and Preventable Diseases:

Hepatitis B Vaccination
Pronounced (hep-ah-TY-tiss)

Hepatitis B is a serious disease caused by a virus that attacks the liver. The virus, which is called hepatitis B virus (HBV), can cause lifelong infection, cirrhosis (scarring) of the liver, liver cancer, liver failure, and death.

Hepatitis B vaccine is available for all age groups to prevent HBV infection.

Hepatitis B vaccination

What You Should Know

About the Disease

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Vaccine Information

The vaccination schedule most often used for adults and children has been three intramuscular injections, the second and third administered 1 and 6 months after the first. Recombivax HB® has been approved as a two dose schedule for aged 11-15 years. Twinrix® has also been approved as a four dose accelerated schedule.

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Beliefs & Concerns

There is no confirmed evidence which indicates that hepatitis B vaccine can cause chronic illnesses.

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Vaccine Safety

As with all vaccines, there can be minor reactions, including pain and redness at the injection site, headache, fatigue or a vague feeling of discomfort.

Who Should Not be Vaccinated?

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For Health Professionals

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Hepatitis B and Pregnancy

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Vaccine Recommendations on Hepatitis B

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References and Resources

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Provider Education

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Materials for Patients

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This page last modified on July 6, 2012
Content last reviewed on April 22, 2007
Content Source: National Center for Immunization and Respiratory Diseases


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Vaccines and Immunizations