HPS Technical/Clinical Information
In May of 1993, an outbreak of unexplained illness occurred in the four corners region of the southwestern United States. A cluster of cases presented with influenza type illness that progressed rapidly to a more severe respiratory disease. Within a couple of weeks a newly identified virus, Sin Nombre, was shown to be the cause of Hantavirus Pulmonary Syndrome (HPS) and the rodent reservoir was shown to be the common Deer Mouse, Peromyscus maniculatus. Over the years HPS appeared to occur throughout the United States and was found to be caused by at least 10 different strains, each associated with different rodent species. Below is technical and clinical information that describes HPS in depth.
Clinical Manifestation
presentation, evaluation, assessment, abnormalities…
Treatment
broad-spectrum antibiotic therapy, antipyretics…
Histopathology
pulmonary findings, findings in the spleen, liver, lymph nodes…
Pathology/Pathogenesis
immunohistochemistry analysis, electron micgrographic studies…
Diagnostics
serologic assays, isolation, IHC, PCR…
Epidemiology
case characteristics, newly recognized disease, risk factors…
Ecology
reservoir and reservoir distributions, infection…
Prevention
risk reduction in the laboratory…
Technical FAQ
Answers from questions at the HPS clinical update in 1999…
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- Centers for Disease Control and Prevention
Viral Special Pathogens Branch
1600 Clifton Rd
Atlanta, GA 30333 - Hantavirus Hotline
(877) 232-3322
(404) 639-1510 - 800-CDC-INFO
(800-232-4636)
TTY: (888) 232-6348 - cdcinfo@cdc.gov
- About VSPB (Viral Special Pathogens Branch)
