Tom Misteli, Ph.D.
Senior Investigator
Laboratory of Receptor Biology and Gene Expression
NCI, CCR
Research Topics
Cell Biology of Genomes
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.
My laboratory studies the cell biology of genomes. We use molecular techniques in conjunction with live-cell microscopy to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. These studies provide insights into basic biological mechanisms and provide the foundation for novel diagnostic and clinical applications in cancer research.
Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have recently been linked to human aging. We are using several differentiation and disease models, including embryonic and adult stem cells, to elucidate how genome organization contributes to physiological processes and disease, particularly cancer and aging.
Biography
Tom Misteli is an internationally renowned expert in genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he pioneered the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several international agencies and serves on numerous editorial boards.
Selected Publications
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Pegoraro G, Voss TC, Martin SE, Tuzmen P, Guha R, Misteli T. Identification of mammalian protein quality control factors by high-throughput cellular imaging. PLoS One. 2012;7(2):e31684.
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Kubben N, Adriaens M, Meuleman W, Voncken JW, van Steensel B, Misteli T. Mapping of lamin A- and progerin-interacting genome regions. Chromosoma. 2012.
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Misteli T. Parallel genome universes. Nat Biotechnol. 2012;30(1):55-6.
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Hakim O, Misteli T. SnapShot: Chromosome confirmation capture. Cell. 2012;148(5):1068.e1-2.
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Mazumdar M, Sung MH, Misteli T. Chromatin maintenance by a molecular motor protein. Nucleus. 2011;2(6):591-600.
Related Scientific Focus Areas
This page was last updated on May 24th, 2012
