The world's largest clinical research hospital is a complex of buildings on the NIH campus, known as Building 10 or the Clinical Center (CC). With the original Warren Grant Magnuson Clinical Center at the hub, over the years the complex expanded from its original 1955 structure to encompass important additions. The latest is the new Mark O. Hatfield Clinical Research Center, which includes 350 flexible patient bed modules that function as inpatient beds and day hospital stations; research laboratories; a vivarium; animal surgery suite; offices; hospital support services; and radiation oncology.

Also located in Building 10 is the NIH Library, used primarily by NIH scientists and other staff; the Occupational Medical Service; Medical Arts and Photography Service; and other offices.

The nearest NIH Shuttle Stop is located at Building 10.