ToxFAQs™ for Formaldehyde

(Formaldehido)

September 2008

CAS# 50-00-0

PDF Version, 32 KB

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This fact sheet answers the most frequently asked health questions about formaldehyde. For more information, you may call the ATSDR Information Center at 1-800-232-4636. This fact sheet is one in a series of summaries about hazardous substances and their health effects. This information is important because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present.

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Highlights

Everyone is exposed to small amounts of formaldehyde in air and some foods and products. Formaldehyde can cause irritation of the eyes, nose, and throat and neurological effects. Formaldehyde has been found in at least 29 of the 1,669 National Priorities List sites identified by the Environmental Protection Agency (EPA).

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What is formaldehyde?

At room temperature, formaldehyde is a colorless, flammable gas that has a distinct, pungent smell. It is produced by both human and natural sources. Small amounts of formaldehyde are naturally produced by plants, animals, and humans.

It is used in the production of fertilizer, paper, plywood, and urea-formaldehyde resins. It is also used as a preservative in some foods and in many products used around the house, such as antiseptics, medicines, and cosmetics.

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What happens to formaldehyde when it enters the environment?

• Formaldehyde is quickly broken down in the air, usually within hours.
• Formaldehyde dissolves easily but does not last a long time in water.
• Formaldehyde evaporates from shallow soils.
• Formaldehyde does not build up in plants and animals.

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How might I be exposed to formaldehyde?

• The primary way you can be exposed to formaldehyde is by breathing air containing it.
• Releases of formaldehyde into the air occur from industries using or manufacturing formaldehyde, wood products (such as particle-board, plywood, and furniture), automobile exhaust, cigarette smoke, paints and varnishes, and carpets and permanent press fabrics.
• Indoor air contains higher levels of formaldehyde than outdoor air. Levels of formaldehyde measured in indoor air range from 0.02–4 ppm. Formaldehyde levels in outdoor air range from 0.0002 to 0.006 ppm in rural and suburban areas and 0.001 to 0.02 ppm in urban areas.
• Breathing contaminated workplace air. The highest potential exposure occurs in the formaldehyde-based resins industry.

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How can formaldehyde affect my health?

Nasal and eye irritation, neurological effects, and increased risk of asthma and/or allergy have been observed in humans breathing 0.1 to 0.5 ppm. Eczema and changes in lung function have been observed at 0.6 to 1.9 ppm.

Decreased body weight, gastrointestinal ulcers, and liver and kidney damage were observed in animals orally exposed to 50–100 mg/kg/day formaldehyde..

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How likely is formaldehyde to cause cancer?

The Department of Health and Human Services (DHHS) has determined that formaldehyde is a known human carcinogen based on human and animal inhalation studies.

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How does formaldehyde affect children?

A small number of studies have looked at the health effects of formaldehyde in children. It is very likely that breathing formaldehyde will result in nose and eye irritation. We do not know if the irritation would occur at lower concentrations in children than in adults.

There is some evidence of asthma or asthma-like symptoms for children exposed to formaldehyde in homes.

Studies in animals suggest that formaldehyde will not cause birth defects in humans.

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How can families reduce the risk of exposure to formaldehyde?

Formaldehyde is usually found in the air, and levels are usually higher indoors than outdoors. Opening windows and using fans to bring fresh air indoors are the easiest ways to lower levels in the house. Not smoking and not using unvented heaters indoors can lower the formaldehyde levels.

Formaldehyde is given off from a number of products used in the home. Removing formaldehyde sources in the home can reduce exposure. Providing fresh air, sealing unfinished manufactured wood surfaces, and washing new permanent press clothing before wearing can help lower exposure.

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Is there a medical test to show whether I've been exposed to formaldehyde?

Formaldehyde cannot be reliably measured in blood, urine, or body tissues following exposure. Formaldehyde is produced in the body and would be present as a normal constituent in body tissues.

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Has the federal government made recommendations to protect human health?

The EPA has determined that exposure to formaldehyde in drinking water at concentrations of 10 mg/L for 1 day or 5 mg/L for 10 days is not expected to cause any adverse effects in a child.

The EPA has determined that lifetime exposure to 1 ppm formaldehyde is not expected to cause any adverse effects.

The Occupational Health and Safety Administration (OSHA) has limited workers' exposure to an average of 0.75 ppm for an 8-hour workday, 40-hour workweek.

The U.S. Department of Housing and Urban Development (HUD) set standards for formaldehyde emissions in manufactured housing of less than 0.2 ppm for plywood and 0.3 ppm for particle board. The HUD standards are designed to provide an ambient level of 0.4 ppm or less in manufactured housing.

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References

Agency for Toxic Substances and Disease Registry (ATSDR). 2008. Toxicological Profile for Formaldehyde. (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

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Where can I get more information?

If you have questions or concerns, please contact your community or state health or environmental quality department or:

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and and Human Health Sciences
1600 Clifton Road NE, Mailstop F-57
Atlanta, GA 30333
Phone: 1-800-CDC-INFO · 888-232-6348 (TTY)
Fax: 1-770-488-4178
Email: cdcinfo@cdc.gov

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances.

Information line and technical assistance:
Phone: 888-422-8737
FAX: (770)-488-4178

To order toxicological profiles, contact:
National Technical Information Service
5285 Port Royal Road
Springfield, VA 22161
Phone: 800-553-6847 or 703-605-6000

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