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Through its resources for serum reference samples, technologies, informatics, and reference laboratories on validation, the Early Detection Research Network (EDRN) supports investigators by helping them with rapid evaluations of the reproducibility, portability, and precision of their technologies and biomarker assays. EDRN hereby announces the establishment of the Program for Rapid, Independent Diagnostic Evaluation (PRIDE), which is an administrative means by which it can assist extramural investigators in the successful conduct of cross-laboratory validations of biomarkers, including the development, refinements, and uses of new and existing assays, reagents, methods, and tests.