Two randomised control trials suggest that more widespread use of CTC as an alternative to colonoscopy and barium enema (BE) is justified, for detection of colorectal cancer. In an Article, Atkin and colleagues report that 30% of patients who received CTC had additional colonic investigation, compared with 8.2% who received colonoscopy. A second Article by Halligan and colleagues reports that CTC detected substantially more colorectal cancers or large polyps than BE, and has a lower miss rate for colorectal cancer. The findings are discussed in a Comment by Lin.
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A new Lancet non-communicable diseases (NCDs) Series builds on a landmark high-level UN/NCD meeting held in September 2011. The new Series aims to set out clear plans for countrywide implementation of NCD plans in the post-MDG era, towards the unified goal of '25 by 25'—reducing NCD (eg, heart attack, stroke, and cancer) mortality worldwide by 2025. Series leaders Robert Beaglehole and Ruth Bonita discuss the emerging NCD movement in a Podcast.
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Video content
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In a Seminar, Andrew Clegg and colleagues propose that more efficient methods are needed to detect and measure the severity of frailty in routine clinical practice. The Seminar reviews how frailty develops, how it might be prevented, and how it should be reliably detected. Through analysis of landmark studies and frailty models, the authors explore the association between frailty and adverse outcomes, emphasising the need for a shift in the care of frail elderly people towards more appropriate goal-directed care. |
Article
Use of clopidogrel: safety and efficacy of clopidogrel alone, and clopidogrel plus aspirin are investigated in patients taking oral anticoagulant...
Seminar
Yaws: causes and management of this infectious disease spread by skin-to-skin contact, are discussed in a Seminar.
World Report
Medical relief in Syria’s conflict: a doctor reports on the medical aid effort inside the country, and on the Turkish border.
News and Features
Obesity in cities: methods used worldwide; Fukushima aftermath: radiation concerns; Dyslipidaemia: drug suspended; Fructose: effect on...
In Focus
Sports and feel-good hormones;
Profile: Jean-Pierre Chanoine;
Books: clinical endocrinology for a new generation.
...
Article
Intensive insulin therapy in type 2 diabetes: effect of short-term intensive insulin therapy on pathophysiology is discussed in an Article...
Article
S aureus sequencing: Simon Harris and colleagues use whole-genome sequencing to analyse transmission dynamics of an outbreak of meticillin-resistant...
Article
M tuberculosis sequencing: whole-genome sequencing to delineate outbreaks of Mycobacterium tuberculosis.
Newsdesk
Influenza app: use of technology to track spread of disease.
Killings in Pakistan: setback for global polio eradication.
Healthmap: the...
Review
Amyotrophic lateral sclerosis: the Fort Denison meeting group re-evaluate longstanding concepts about the cause and natural history of ALS...
Article
Active convulsive epilepsy: Charles Newton and colleagues assess risk factors and prevalence of the disease in sub-Saharan Africa.
Review
Acute ischaemic stroke: neuroprotective mechanisms and the clinical promise of therapeutic hypothermia.
Article
Prostate cancer: a randomised trial assessing the efficacy and safety of 2-weekly versus 3-weekly docetaxel in advanced, castration-resistant...
Health-care Development
Radiotherapy capacity: Analysis of 33 European countries and recommendations for improvement.
Breaking News
Patients face cancer alone
Breast cancer: trastuzumab emtansine trial.
Clinical trials: approval delays.
2012 Research Highlights
ARDS; Asthma; Bronchiectasis; COPD; Drug-resistant tuberculosis; Mechanical ventilation; NSCLC; Obstructive sleep apnoea...
Breaking News
New drug approved for MDR-TB;
China: wakes up to air pollution;
Apps: to encourage smoking?;
Books: explaining asthma
■ Archive content...
Article
MBL genotypes: Mannose-binding lectin deficiency and severity of non-CF bronchiectasis is discussed in an Article, a Comment, and a Podcast.
Article
Diversifying lipid management: two reports by Robert Giugliano and Michael Koren and colleagues (LAPLACE-TIMI 57 and MENDEL) address a possible...
Comment
Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data.
Article
Duration of in-hospital resuscitation: if the cause of cardiac arrest is potentially reversible, it might be worthwhile to try for a little...
"NCDs [non-communicable diseases] are linked to the way we eat, the way we exercise, the way we live, and to the accessibility and organisation of care. Effective control of NCDs requires a comprehensive approach."
Read more of this letter
"Our job as clinician-scientists is not to please or displease anyone who is in favour of or against, our job is simply to let the data speak for itself..."
Read more of this letter
"...our view is that perfusion imaging should be omitted from routine practice until further studies show its added clinical value"
Read more of this letter
"Establishment of a standard of care for elderly patients with newly diagnosed high-grade glioma would constitute a substantial achievement. On the basis of the NOA-08 trial, this achievement might be realised sooner rather than later."
Read more of this letter
Papers published on The Lancet UK Policy Matters microsite raise concerns about the quality of past evaluations commissioned directly or indirectly by the Department of Health. Read the papers and accompanying blog post to find out more.
UK Policy Matters is a Lancet-based project which explores how UK policy changes affect health. On our microsite you will be able to access evidence-based summaries of different policies and tell us your experiences of how changes in policy have affected health.
If you have evidence of how policy has affected health or health care, we would like to hear from you. We are interested in all forms of evidence, including brief summaries of evidence from academics; and information from the public, managers, and healthcare workers about changes in services and their impact (individual experiences are welcomed).
See the Submit your evidence section of the site to share your experiences and submit your evidence.
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Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
Article
(2012)
The Lancet Infectious Diseases
12 (1), pp. 36-44
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| 2. |
Return to Alma-Ata
Comment
(2008)
The Lancet
372 (9642), pp. 865-866
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| 3. |
The 21st century hazards of smoking and benefits of stopping: a prospective study of one million women in the UK
Article
(2013)
The Lancet
381 (9861), pp. 133-141
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| 4. |
High-risk drug practices tighten grip on London gay scene
World Report
(2013)
The Lancet
381 (9861), pp. 101-102
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GBD 2010: understanding disease, injury, and risk
Comment
(2012)
The Lancet
380 (9859), pp. 2053-2054
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| 1. | Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Research (1998) Lancet 352 (9131), pp. 837-853
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| 2. | MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
Research (2002) Lancet 360 (9326), pp. 7-22
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| 3. | Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Research (1998) Lancet 351 (9118), pp. 1755-1762
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| 4. | Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
Research (2001) Lancet 358 (9286), pp. 958-965
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| 5. | A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
Research (1996) Lancet 348 (9038), pp. 1329-1339
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A 56-year-old man presented with a 29 day history of urgency and twice-hourly micturition. Physical examination was shown a cystic mass in the lower left abdomen. Intravenous urography showed right kidney hydronephrosis and hydroureter.
View Clinical Picture
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AnnouncementsThe Lancet Middle East Editorial Page: sickle cell anaemia in the Middle East. Global Campaign for MDGs report: fulfilling promises from the Millennium Declaration in 2000. Saving millions more lives: The Lancet's Comment on the MDG report. Call for papers: The Lancet and The Lancet Respiratory Medicine invite submissions ahead of the American Thoracic Society meeting; the deadline is the end of February. World Health Summit Regional Meeting: the first regional meeting will be held in Singapore April 8-10, 2013. Call for abstracts is now open. |
