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We invite you to take part in a research study at [name of research institution].
Before you decide to take part, please take as much time as you need to ask any questions and discuss this study with anyone at [institution] or with family, friends, or your personal physician or other health professional.
If you are signing this consent form as the parent or guardian of a minor who will participate, "you" in this consent form refers to your child. When your child turns 18 years old, she or he will be able to make decisions regarding ongoing participation in this research for herself or himself.
[Instructions to investigators: If there is a preliminary plan to use samples now for a specific project, state the purpose of that project first, in addition to the following generic language.]
The purpose of this research is to create, use, and share induced pluripotent stem cells, also known as "iPS" cells.
"Pluripotent" stem cells are cells that can be converted into many different kinds of cell types, such as muscle, nerve, and liver cells. They can be kept alive and stored indefinitely in the laboratory and in stem cell banks. There are different kinds of pluripotent stem cells. Induced pluripotent stem cells (iPS cells) can be derived from many different kinds of donated samples, such as skin, blood, or hair. This is different from embryonic stem cells, which can only be derived from embryos. This study involves the creation and use of iPS cells that are derived from donated samples.
We can learn a lot by studying iPS cells that are made from samples collected from people with different conditions, and people without these conditions. iPS cells are used for research on various medical conditions and potential treatments for those conditions. They are also used to develop better techniques for making iPS cells and to train researchers in how to make them.
In the future, iPS cells may be used in other ways. For example, research may include:
Your iPS cells may be used in research on possible treatments for various diseases and conditions. This may include transplanting cells or tissues made from iPS cells directly into another patient to treat a disease (known as "regenerative medicine"). At this time, there are no plans to use your iPS cells in this way, but it may be done in the future.
Society and medical research benefit from sharing cells and information among many researchers and institutions. The iPS cells and medical information from participants in this study will be made available to researchers at universities, private companies, and other institutions in the United States and internationally. We may share your cells with our own research collaborators. We will set up a repository of the iPS cells, also known as a "stem cell bank," so that other researchers and companies can apply to use the banked iPS cells in their own research.
The stem cell bank will only release cells to researchers and others under certain conditions. [Investigator instructions: Specify the terms of release established by the repositories.]
[If applicable:] Information about your DNA will be put into a database called "dbGaP," along with information from the other research participants. This information will be available to other researchers who have received approval from an NIH Data Access Committee.
This study involves obtaining a sample from you, as well as collecting information on your medical history from you and your medical records. The samples will be used to create iPS cells.
[Instructions to investigators: Check those that are appropriate from the list below, and instruct the participant to initial next to the box(es) checked to indicate their acknowledgement.] With this consent form, you are asked to provide blood, skin biopsies, or hair samples as indicated in the checked boxes below. Please initial on the line to indicate that you agree to the procedure.
[Will vary by institution/study] If you are having a biopsy or other surgery, we will ask for your permission to use a part of the blood or tissue samples being removed to create iPS cells for research. We will only use this blood or tissue for research if it is not needed for your care or treatment.
We will interview you about your medical history. We will review your medical records. We will ask about your family’s racial and ethnic background and where they came from. We will provide limited medical information about you, such as your sex, age at the time of sample donation, and diagnosis to the cell bank and to other researchers along with iPS cells and samples.
Obtaining these samples usually requires one outpatient visit. We will obtain the samples during a visit scheduled for another reason whenever possible.
We may want to contact you in the future.
Remember that you can re-contact the research team at any time, now or in the future, and ask any questions you have.
With this consent form, you are asked to agree to be re-contacted by the researchers in the future for a variety of reasons. However, if you do not wish to be re-contacted, please indicate your preference below:
Check and initial here if you DO NOT agree to be re-contacted in the future by the research team for any reason.
All research on your cells must comply with all applicable laws and policies. The iPS cells generated from your tissue samples will never be used to clone (known as "reproductive cloning") or to otherwise create an entire human being. Research with human iPS cells may involve transplanting or testing them with animals, within the limits imposed by laws and regulations.
The stem cell bank that we will be creating with iPS cells from this study is not the same as storing umbilical cord blood or other stem cell storage services. You will not be able to retrieve your donated samples or iPS cells from the researchers for personal use.
By agreeing to be in this study, you agree to the terms and limitations described in this consent form. We are not able to honor personal restrictions. For example, you may not place restrictions on who may or may not be treated with your cells or resulting medical products. You also may not place limits on the types of diseases that may be studied with your cells. If you have questions about these terms, please feel free to ask us.
Your name, birth date, and other personally-identifying information will be removed from your data and samples. They will be linked to your sample only by code number. The code key for the samples will be stored in password-protected database under control of the [institution] investigators. Medical information, samples, and iPS cells that are shared with others will be coded and will not include identifying information (name, address, telephone number, or personal identification number). Only the original investigators will be able to trace your samples and information to you.
Information collected in this study may be reviewed by authorized individuals from the Food and Drug Administration (FDA), the National Institutes of Health (NIH), or other agencies for the purpose of making sure that proper systems, procedures, and regulations are being followed.
Participation in this study will not benefit you or your family directly.
It will take a long time for research to progress and to yield safe, effective treatments based on iPS cells obtained in this study. Your participation will help medical research better understand various diseases and develop better treatments, which may help you or others in the future.
Taking part in research is entirely voluntary. You do not have to participate in this study if you do not want to do so. Your decision about whether or not to participate will in no way affect your present or future medical care at [related hospital/clinical center, as applicable], your participation in other research studies at the [institution], or your relationship with the research team.
If you join the study but change your mind later and wish to withdraw, please let us know. We are able to honor such requests as follows:
We will NOT be able to destroy iPS cells once they are created. iPS cells that have been shared with other researchers will not be retrievable.
[Instructions to investigators: Indicate whether or not participants will be paid for their participation in this study. For example: "You will not be paid for taking part in this study."]
Your samples will be used for research, and they may also be used to make commercial products and treatments, meaning that they can be bought and sold in order to treat other people. The research done with your samples may help to develop new products in the future. You will not receive any financial compensation, should this occur.
If you have any problems or questions about this study, or about your rights as a research participant, or about any research-related injury, contact the Principal Investigator, Building, Room, Telephone. You may also call the [INSTITUTION] Patient Representative at xxx-xxx-xxxx. Please keep a copy of this document in case you want to read it again.
SIGNATURES [per institutional format]
Supplement to: Lowenthal J, Lipnick S, Rao M, Hull SC (2012) "Specimen Collection for iPSC Research: Harmonizing the Approach to Informed Consent"
This page was last modified on October 17, 2012