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The conference artwork depicts several possible approaches to preventing Alzheimer's disease and cognitive decline as viewed through a window. These approaches include mental stimulation, exercise, and biomedical research. The conference will examine the current evidence supporting the use of these and other preventive measures for Alzheimer’s disease and cognitive decline. The image was conceived and created by NIH’s Division of Medical Arts and is in the public domain. Please credit 'NIH Medical Arts.'
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NIH State-of-the-Science Conference
Preventing Alzheimer’s Disease
and Cognitive Decline

April 26–28, 2010
Bethesda, Maryland

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Final Statement | PDF
Program & Abstracts | PDF
Archived Webcast Day 1 | 2 | 3
Background
Sponsors
Agenda
Evidence Report
Planning Committee | Panel
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Sponsors

 

National Institute on Aging logospacer         NIH Consensus Development Program
National Institute on Aging
Office of Medical Applications of Research


Co-sponsors

Eunice Kennedy Shriver National Institute of Child Health and Human Development logo      National Center for Complementary and Alternative Medicine logo     National Institute of Mental Health    National Institute of Neurological Disorders and Stroke     National Institute of Nursing Research       NIH Office of Dietary Supplements
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Center for Complementary and Alternative Medicine
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke

National Institute of Nursing Research
Office of Dietary Supplements

Partners

Centers for Medicare and Medicaid Services logo          Centers for Disease Control and Prevention logo          Agency for Healthcare Research and Quality logo
Centers for Disease Control and Prevention
Centers for Medicare and Medicaid Services

The Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention provided additional conference development support.


Agenda

 

Monday, April 26, 2010

8:30 a.m. Opening Remarks
Richard Hodes, M.D.
Director
National Institute on Aging
National Institutes of Health
8:40 a.m. Charge to the Panel
Jennifer M. Croswell, M.D., M.P.H.
Acting Director
Office of Medical Applications of Research
Office of the Director
National Institutes of Health
8:50 a.m. Conference Overview and Panel Activities
Martha L. Daviglus, M.D., Ph.D., M.P.H.
Panel and Conference Chairperson
Professor of Preventive Medicine and Medicine
Department of Preventive Medicine
Feinberg School of Medicine
Northwestern University
Chicago, Illinois
General Overview
9:00 a.m. Alzheimer's Disease: Nature of the Public Health Problem
Mary Ganguli, M.D., M.P.H.
University of Pittsburgh Medical Center
Department of Psychiatry
Western Psychiatric Institute and Clinic
9:20 a.m. Alzheimer's Disease: Early Diagnosis
Ronald Petersen, M.D., Ph.D.
Director, Alzheimer's Disease Research Center
Department of Neurology
Mayo Clinic College of Medicine
9:40 a.m. Age-Related Cognitive Decline: Nature of the Problem
Marilyn Albert, Ph.D.
Professor of Neurology
Division of Cognitive Neuroscience
Johns Hopkins University School of Medicine
10:00 a.m. Discussion
10:30 a.m. Age-Related Cognitive Decline: Measurements of Change
Dan Mungas, Ph.D.
Adjunct Professor
Department of Neurology
Director, UC Davis Alzheimer's Disease Center
University of California Davis School of Medicine
10:50 a.m. Pathophysiology of Alzheimer's Disease and Age-Related Cognitive Decline
David A. Bennett, M.D.
Robert C. Borwell Professor of Neurological Sciences
Director, Rush Alzheimer's Disease Center
Department of Neurological Sciences
Rush Medical Center
11:10 a.m. Interventions in Animal Models of Alzheimer's Disease
Carl Cotman, Ph.D.
Professor
Institute for Brain Aging and Dementia
University of California, Irvine
11:30 a.m. Discussion
12:00 p.m. Lunch
Panel Executive Session
What Factors Are Associated With the Reduction of Risk of Alzheimer's Disease?
  and
What Factors Are Associated With the Reduction of Risk of Cognitive Decline in Older Adults?
1:00 p.m. Nutritional/Dietary Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Foods
Martha Clare Morris, Sc.D.
Rush Institute for Healthy Aging
Rush Medical Center
1:20 p.m. Nutritional /Dietary Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Complementary and Alternative Medicine
Joseph Quinn, M.D.
Assistant Professor
Department of Neurology
Oregon Health and Science University
1:40 p.m. Evidence-based Practice Center Presentation I: Methodology of Systematic Review and the Factors Associated With the Reduction of Risk of Alzheimer’s Disease and Cognitive Decline
John W. Williams, Jr., M.D., M.H.S.
Professor
Department of General Internal Medicine
Duke University
2:00 p.m. Discussion
2:30 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Physical Activity
Arthur Kramer, Ph.D.
Beckman Institute
University of Illinois
2:50 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Social Engagement and Leisure Activities
Laura Fratiglioni, M.D., Ph.D.
Karolinska Institute
3:10 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Cognitive Engagement
Yaakov Stern, Ph.D.
Professor
Department of Aging and Dementia
Sergievsky Center
Columbia University College of Physicians and Surgeons
3:30 p.m. Discussion
4:00 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Vascular Factors
Charles DeCarli, M.D.
Professor of Neurology
Department of Neurology
Director
Alzheimer's Disease Center
Imaging of Dementia and Aging (IDeA) Laboratory
Center for Neuroscience
University of California at Davis
4:20 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Depression
Constantine Lyketsos, M.D.
Professor of Psychiatry and Behavioral Sciences
Chair, Department of Psychiatry
Johns Hopkins Bayview Medical Center
4:40 p.m. Risk Reduction Factors for Alzheimer's Disease and Cognitive Decline in Older Adults: Sociocultural and Demographic
Jennifer Manly, Ph.D.
Associate Professor
Department of Neurology
Sergievsky Center
Columbia University College of Physicians and Surgeons
5:00 p.m. Discussion
5:30 p.m. Adjournment


Tuesday, April 27, 2010

What Are the Therapeutic and Adverse Effects of Interventions to Delay the Onset of Alzheimer's Disease? Are There Differences in Outcomes Among Identifiable Subgroups?
8:30 a.m. Clinical Trials for Alzheimer's Disease
Paul Aisen, M.D.
Professor
Department of Neurosciences
University of California, San Diego School of Medicine
What Are the Therapeutic and Adverse Effects of Interventions to Improve or Maintain Cognitive Ability or Function? Are There Differences in Outcomes Among Identifiable Subgroups?
8:50 a.m. Clinical Trials in Cognitive Aging
Frederick Unverzagt, Ph.D.
Director, Neuropsychology Clinic in Psychiatry
Training Director, Clinical Neuropsychology
Associate Professor of Psychiatry
Department of Psychiatry
Indiana University School of Medicine
9:10 a.m. Evidence-based Practice Center Presentation II: The Therapeutic and Adverse Effects of Interventions To Delay the Onset of Alzheimer’s Disease or To Improve Cognitive Ability, and the Differences Among Identifiable Subgroups

James Burke, M.D., Ph.D.
Associate Professor of Medicine-Neurology
Director
Duke Memory Disorders Clinic
Duke University

9:30 a.m. Discussion
What Are the Relationships Between the Factors That Affect Alzheimer's Disease and the Factors That Affect Cognitive Decline?
10:00 a.m.

Evidence-based Practice Center Presentation III: The Relationship Between the Factors That Affect Alzheimer’s Disease and Cognitive Decline|

Tracey Holsinger, M.D.
Assistant Professor
Department of Geriatric Psychiatry
Duke University
Durham Veterans Affairs Medical Center

10: 20 a.m. Factors That Protect Against Alzheimer's Disease and Cognitive
Decline
David A. Bennett, M.D.
Robert C. Borwell Professor of Neurological Sciences
Director, Rush Alzheimer's Disease Center
Department of Neurological Sciences
Rush Medical Center
10:40 a.m. Commentary: Evidence-based Practice Center Systematic Review
Hugh Hendrie, D.Sc., M.B., Ch.B.
Professor, Department of Psychiatry
Indiana University School of Medicine
Center Scientist
Indiana University Center for Aging Research
Research Scientist
Regenstrief Institute, Inc.
11:00 a.m. Discussion
11:30 a.m. Adjournment


Wednesday, April 28, 2010

9:00 a.m. Presentation of the Draft State-of-the-Science Statement
9:30 a.m. Public Discussion
11:00 a.m. Adjournment
Panel Meets in Executive Session
2:00 p.m. Press Telebriefing

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