NINDS Periventricular Leukomalacia Information Page

What is Periventricular Leukomalacia?

Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns; premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the periventricular area of the brain, which results in the death or loss of brain tissue. The periventricular area-the area around the spaces in the brain called ventricles-contains nerve fibers that carry messages from the brain to the body's muscles. Although babies with PVL generally have no outward signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments. PVL may be accompanied by a hemorrhage or bleeding in the periventricular-intraventricular area (the area around and inside the ventricles), and can lead to cerebral palsy. The disorder is diagnosed by ultrasound of the head.

Is there any treatment?

What is the prognosis?

What research is being done?

• NINDS Cerebral Palsy Information Page
  Cerebral palsy information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
• Cerebral Palsy: Hope Through Research
  
  Cerebral palsy information booklet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).