Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis, and as a result, mitochondrial variations that affect these functions may contribute to the development and progression of cancer. In most cases, reactive oxygen species and DNA adducts induce mitochondrial mutations. Other agents that may result in mutations include radiation, infectious agents, and …
Category Archive: Cancer Genetic Alterations
Permanent link to this article: http://blog-epi.grants.cancer.gov/2012/05/01/a-tale-of-two-genomes-mitochondrial-genomics-and-cancer-risk/
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