TRND Application Scoring Matrix
Score 1-3 High Score | Score 4-6 Average Score | Score 7-9 Poor Score | |
---|---|---|---|
Target and Therapeutic Validation (30%) | Target has been validated in both animal pharmacology studies as well as in humans and there is a link to therapeutic indication. | Target has been validated primarily in animal pharmacology or knock out mouse studies. | Target has been validated in primarily in vitro in animals and/or humans. |
Strength of current data package (30%) | High quality in the relevant areas:
| High quality in some of the relevant areas and medium quality in other relevant areas:
| Medium or marginal quality in the relevant areas
|
Feasibility to reach First in Human (20%) | Have most of the following:
| Have many of the following:
| Have few to none of the following:
|
Medical impact relative to current Standard of Care (10%) | There is no current treatment for the disease or clinical outcome. Or the current standard of care has considerable disadvantages or very limited utility | The current standard of care has potential disadvantages (resistance). Or the current standard of care somewhat limited utility | The current standard of care is adequate, but additional treatments are desired. |
Likelihood of external adaption (10%) | Will themselves or has a committed partner that will take this compound to registration | Compounds of this nature have been adopted by partners and taken to registration Or a partner has expressed interest | No interest has been noted for the compound or the disease |
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