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The DTP Human Tumor Cell Line Screen has checked tens of thousands of compounds for evidence of the ability to inhibit the growth of human tumor cell lines. Available here are screening results and chemical structural data on compounds that are not covered by a confidentiality agreement. We anticipate that this list will be updated at least once a year.

Searchable Results

• Mechanism of Action
• Chemical indentifier (NSC number, CAS number , chemical name)

Screening Results (September 2012 Release)

The compounds submitted to the cancer screen are generally tested at five different concentrations for the ability to inhibit sixty different human tumor cell lines. The dose respose data is used to calculate three concentration parameters.

• GI₅₀
• TGI
• LC₅₀

The Cancer Screening Results (September 2012 Release) can be downloaded in bulk via compressed files. Caution: Each of these files is about 20MB and uncompresses to about 185 MB

• GI₅₀ data
• TGI data
• LC₅₀ data

Each is a gzip compressed ASCII file containing the results for ~43,000 compounds. The usual .Z (or .gz) file type was changed to .BIN to make sure Netscape doesn't try to uncompress on the fly and write the 185 MB to your screen. You should save the file to your disk and uncompress, which will result in an ASCII file with 11 comma delimited fields per record:

Please note the links for more information on the SNB-19, U251, NCI/ADR-RES, and MDA-MB-435 cell lines.

• MDA-MB-435
• U251
• SNB-19
• NCI/ADR-RES

• NSC number - the NCI's internal ID number
• Concentration Unit - Either M for molar or u for µ g/ml
• log of the highest concentration tested
• panel name for the cell line
• cell line name
• panel number of the cell line (see table)
• cell number of the cell line (see table)
• -log of the result (GI₅₀, TGI, LC₅₀ depending on the file)
• number of tests for this NSC and cell line
• maximum number of tests for this NSC
• StdDev Standard Deviation of the Log₁₀ of the results averaged across all tests for this NSC and cell line

Dose Reponse Set Data

The Dose Reponse Screening Results (September 2012 Release) can be downloaded in bulk via two compressed files.

• Dose Response data
• Dose Response Many Test data

One Dose Set Data

The One Dose Screening Results (September 2012 Release) can be downloaded in bulk via a compressed file. Caution: This file is about 5MB and uncompresses to about 50MB

• One Dose data

The file is a gzip compressed ASCII file containing the results for ~43,000 compounds. The usual .Z (or .gz) file type was changed to .BIN to make sure Netscape doesn't try to uncompress on the fly and write the 50 MB to your screen. You should save the file to your disk and uncompress, which will result in an ASCII file with 11 comma delimited fields per record:

• NSC number - the NCI's internal ID number
• Concentration Unit - Either M for molar or u for µ g/ml
• log of the highest concentration tested
• panel name for the cell line
• cell line name
• panel number of the cell line (see table)
• cell number of the cell line (see table)
• -log of the result (GI₅₀)
• number of tests for this NSC and cell line
• maximum number of tests for this NSC
• StdDev Standard Deviation of the Log₁₀ of the results averaged across all tests for this NSC and cell line

Diversity Set Data

The Diversity Set Results (August 1999 Release) can be accessed as text files. Each file is approximately 5.6Mb.

• GI₅₀ data
• TGI data
• LC₅₀ data

Chemical Structural Data

Cancer Screen (December 2010 Release)

The 2D structures were retrieved from the DTP's Drug Information System.

• Download the file for compounds tested in the One Dose assay
• Download the file for compounds tested in the Five Dose assay