Question ID: WS-54
Submitted by: David Chia
February 8, 2011
Question: Why are mRNA expression pattern in blood of cancer patient not being exploited more for early detection and prognosis? Background: Currently tumor can be phenotype by gene expression pattern, and had been useful in the prognoses of diseases. Specific gene expression in blood had been reported, but had not made much progressed since. This may due to the difficulty in isolating RNA from blood. Exosome from tumor had been found in blood. Thus studying mRNA pattern from exosome from cancer patient’s blood, one may be able to phenotype the tumor. Feasibility: Advance in isolation of exosomes from blood will make this task possible. Implication of success: The ability to phenotype tumor using blood will have major implication in early detection, and prognosis of cancer.
Average Score: 4.5
 (1 evaluation)Provocativeness - 4.0
Novelty - 4.0
Public Health Significance - 5.0
Feasibility - 5.0
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Comments
Submitted By Anil Wali
I agree with your analysis, exosomes represent a viable resource to identify early detection biomarkers for various malignancies and this field should be explored further aggressively.
