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Question ID: WS-71
Submitted by: Pier-Luigi Lollini
March 3, 2011
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Question ID: WS-71
Submitted by: Pier-Luigi Lollini
March 3, 2011
Why do we treat with interferon so many cancer patients that will not respond? The short answer is because interferon is still used as an empyrical, rather than targeted cancer treatment. Many predictors of response were defined, including the induction of autoimmune responses, tumor expression of interferon receptor, leukocyte infiltration of the primary, and the spectrum of circulating cytokines. Further predictors are related to general patient status and disease extension (time since diagnosis, performance status, circulating tumor cells, LDH, serum hemoglobin and calcium). Now it is the time to validate efficient predictors and to revise eligibility for interferon therapy.
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