Question ID: WS-97
Submitted by: Eleanor Rogan
June 28, 2011
What role does estrogen genotoxicity play in the initiation of breast and other human cancers? BACKGROUND: The reaction of specific metabolites of estrogen with DNA to form adducts is identical to that of the analogous metabolites of the leukemogenic benzene and the human carcinogen diethylstilbestrol. This reaction can lead to specific mutations that may initiate cancer. Elevated levels of estrogen-DNA adducts are found in women at high risk of breast cancer, as well as women diagnosed with the disease. FEASIBILITY: Mechanistic studies of mutations, transformation and carcinogenesis in human cell culture systems and studies of estrogen-DNA adducts in cancer cases and controls can be used to demonstrate the role of estrogen genotoxicity in the initiation of cancer. IMPLICATIONS FOR PUBLIC HEALTH: Demonstrating the role of estrogen genotoxicity in the initiation of breast and other human cancers can lead to biomarkers for risk of developing cancer and to prevention strategies.
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