AGENDA
Chairs Workshop Chairs: Jose Florez, Kathleen Giacomini, and Alan Shuldiner NIDDK Organizers: Aaron Pawlyk, Catherine McKeon, Myrlene Staten, and Arthur Castle
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Wednesday, June 6, 2012 |
On your own for dinner. |
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Thursday, June 7, 2012 |
8:00 a.m. |
Welcome and Orientation Griffin Rodgers, NIDDK Aaron Pawlyk, NIDDK |
Session I: |
Understanding the Uses and Responses of Metformin |
Moderator: |
Alan Shuldiner, University of Maryland |
8:00 a.m. |
Welcome and Orientation |
8:15 a.m. |
Introduction to Metformin and Its Clinical Use Ronald Goldberg, University of Miami Miller School of Medicine |
8:45 a.m. |
Where Are We With Metformin PGx and Where Can We Go? Ewan Pearson, University of Dundee, United Kingdom |
9:30 a.m. |
Metformin Pharmacogenomics: Ethnicity and Transporter Gene x Gene Interactions Kathleen Giacomini, University of California, San Francisco |
10:00 a.m. |
Pharmacometabolomics and Its Integration With Pharmacogenomics Rima Kaddurah-Daouk, Duke University Medical Center |
10:30 a.m. |
Break |
10:45 a.m. |
Guided Discussion Panel Multitudes of Metformin Populations: Type 2 Diabetes (T2D)– Prevention, Treatment, Pediatrics, Cancer, Aging, Alzheimer’s Disease, and Polycystic Ovarian Disease |
10:45 a.m. |
Challenges Outside of T2D: Diabetes Prevention and Gene Variants Jose Florez, Massachusetts General Hospital |
11:00 a.m. |
Panel Discussion Jose Florez, Massachusetts General Hospital (Prevention) Phil Zeitler, Children's Hospital Colorado (Pediatric) Corrine Welt, Massachusetts General Hospital (Polycystic Ovary Syndrome) Pamela Goodwin, Mount Sinai Hospital (Breast Cancer)
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11:30 a.m. |
Lunch – grab it and come back! |
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Session II: |
Health Care Systems and Information Management |
Moderator: |
Toni Pollin, University of Maryland School of Medicine |
12:15 p.m. |
The eMERGING Role of Health-care Systems in Pharmacogenomics Rex Chisholm, Northwestern University |
12:35 p.m. |
Pharmacy Benefit Manager-based Pharmacogenomics and Personalized Medicine Approaches Eric Stanek, Medco Health Solutions, Inc. |
12:55 p.m. |
Genetic Architecture of Drug Efficacy and Toxicity – Implications For Discovery and Clinical Implementation Robert Plenge, Harvard Medical School/Brigham and Women’s Hospital |
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Session III: |
Models of Collaboration |
Moderator: |
Monique Hedderson, Kaiser Permanente Northern California |
1:10 p.m. |
RIKEN Center for Genomic Medicine and Collaboration With the Pharmacogenomics Research Network Michiaki Kubo, Center for Genomic Medicine, RIKEN, Japan |
1:30 p.m. |
PharmGKB: Lessons From Other Pharmacogenomics Efforts Teri Klein, Stanford University |
1:50 p.m. |
Toward Personalized Medicine in Diabetes: A View From Pharma Dawn Waterworth, GlaxoSmithKline |
2:10 p.m. |
Past, Present, and Future NIH-funded Metformin Trials David Nathan, Harvard Medical School/Massachusetts General Hospital |
2:40 p.m. |
Quick Objectives Overview for Breakout Sessions Aaron Pawlyk, NIDDK |
2:45 p.m. |
Break |
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Session IV: |
Breakout sessions |
3:00 p.m. |
Discussions of key scientific issues and next steps towards understanding the pharmacogenomics of the metformin response:
- Pharmacogenomics to Understand Metformin’s Mechanism and New Drug Target Discovery
Chairs: Jose Florez, Massachusetts General Hospital and Marc Reitman, NIDDK
- Scientific, Informatics, Collaborative, and Logistical Needs for Large-scale Validation of Metformin Pharmacogenomics
Chairs: Kathy Giacomini, University of California, San Francisco and Monique Hedderson, Kaiser Permanente Northern California
- Challenges to Translating Metformin Pharmacogenomics Into the Clinic for Multiple Endpoints and in Diverse Ethnic Backgrounds
Chairs: Alan Shuldiner, University of Maryland and Eric Stanek, Medco Health Solutions, Inc. |
3:45 p.m. |
Break; Meeting Chairs prepare summary |
4:00 p.m. |
Presentations of Discussions at Breakouts and Moderated Discussion Moderators: External Scientific Chairs |
4:45 p.m. |
Adjournment |
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Organizers Draft Workshop Report. |