This program supports basic and clinical studies on the pathogenesis, prevention, and treatment of acute kidney injury. Interests include (1) standardized definitions; (2) natural history including risk and outcome stratification for both early disease and progression to chronic renal disease; (3) causes, pathogenetic mechanisms, and pathophysiology in humans and animal models; (4) functional, structural, and imaging markers and strategies for diagnosis, early detection, severity, prognosis, and outcomes; (5) underlying mechanisms leading to prevention, treatment, or enhanced recovery of AKI, and progression to chronic renal disease, including use of pharmaceutical agents, stem cells, and imaging techniques; (6) identification and testing of possible preventive, pre-emptive, or therapeutic interventions that prevent the development, halt progression, or speed recovery of AKI; (7) studies of renal support or replacement strategies to determine the physiological changes or optimal timing, modality, or dose; and (8) economic analyses of the impact of disease and its treatment.
For more information on basic studies, contact Dr. Krystyna Rys-Sikora, Program Director, Basic Acute Kidney Injury.
For further information on translational or clinical studies, contact Dr. Paul Kimmel, Program Director, Clinical Acute Kidney Injury.
