NIH Director's Pioneer Award Program

Publications


 
Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors.
Depry, Charlene; Mehta, Sohum; Zhang, Jin
Pflugers Archiv : European journal of physiology. 2013 Mar. 373-81 
PMID: 23138230 [PubMed]
Multiplex genome engineering using CRISPR/Cas systems.
Cong, Le; Ran, F Ann; Cox, David; Lin, Shuailiang; Barretto, Robert; Habib, Naomi; Hsu, Patrick D; Wu, Xuebing; Jiang, Wenyan; Marraffini, Luciano A; Zhang, Feng
Science (New York, N.Y.). 2013 Feb 15. 819-23 
PMID: 23287718 [PubMed]
Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi.
Chooi, Yit-Heng; Fang, Jinxu; Liu, Hong; Filler, Scott G; Wang, Pin; Tang, Yi
Organic letters. 2013 Feb 15. 780-783 
PMID: 23368997 [PubMed]
Radioluminescent gold nanocages with controlled radioactivity for real-time in vivo imaging.
Wang, Yucai; Liu, Yongjian; Luehmann, Hannah; Xia, Xiaohu; Wan, Dehui; Cutler, Cathy; Xia, Younan
Nano letters. 2013 Feb 13. 581-5 
PMID: 23360442 [PubMed]
Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment.
Wang, Yucai; Black, Kvar C L; Luehmann, Hannah; Li, Weiyang; Zhang, Yu; Cai, Xin; Wan, Dehui; Liu, Si-Yun; Li, Max; Kim, Paul; Li, Zhi-Yuan; Wang, Lihong V; Liu, Yongjian; Xia, Younan
ACS nano. 2013 Feb 12.  
PMID: 23383982 [PubMed]
Synthesis of Ag Nanocubes 18-32 nm in Edge Length: The Effects of Polyol on Reduction Kinetics, Size Control, and Reproducibility.
Wang, Yi; Zheng, Yiqun; Huang, Cheng Zhi; Xia, Younan
Journal of the American Chemical Society. 2013 Feb 6. 1941-51 
PMID: 23317148 [PubMed]
Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates.
Gao, Zhizeng; Wang, Jingjing; Norquay, Amy K; Qiao, Kangjian; Tang, Yi; Vederas, John C
Journal of the American Chemical Society. 2013 Feb 6. 1735-8 
PMID: 23356934 [PubMed]
Mechanistic Evaluation of the Pros and Cons of Digital RT-LAMP for HIV-1 Viral Load Quantification on a Microfluidic Device and Improved Efficiency via a Two-Step Digital Protocol.
Sun, Bing; Shen, Feng; McCalla, Stephanie E; Kreutz, Jason E; Karymov, Mikhail A; Ismagilov, Rustem F
Analytical chemistry. 2013 Feb 5. 1540-6 
PMID: 23324061 [PubMed]
Physics. Measuring mass in seconds.
Debs, John E; Robins, Nicholas P; Close, John D
Science (New York, N.Y.). 2013 Feb 1. 532-3 
PMID: 23372004 [PubMed]
Systematic identification of signal-activated stochastic gene regulation.
Neuert, Gregor; Munsky, Brian; Tan, Rui Zhen; Teytelman, Leonid; Khammash, Mustafa; van Oudenaarden, Alexander
Science (New York, N.Y.). 2013 Feb 1. 584-7 
PMID: 23372015 [PubMed]
Large-scale brain networks in affective and social neuroscience: towards an integrative functional architecture of the brain.
Barrett, Lisa Feldman; Satpute, Ajay Bhaskar
Current opinion in neurobiology. 2013 Jan 23.  
PMID: 23352202 [PubMed]
Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes.
Mucida, Daniel; Husain, Mohammad Mushtaq; Muroi, Sawako; van Wijk, Femke; Shinnakasu, Ryo; Naoe, Yoshinori; Reis, Bernardo Sgarbi; Huang, Yujun; Lambolez, Florence; Docherty, Michael; Attinger, Antoine; Shui, Jr-Wen; Kim, Gisen; Lena, Christopher J; Sakag
Nature immunology. 2013 Jan 20.  
PMID: 23334788 [PubMed]
Controlling enzymatic action in living cells with a kinase-inducible bimolecular switch.
Sample, Vedangi; Ni, Qiang; Mehta, Sohum; Inoue, Takanari; Zhang, Jin
ACS chemical biology. 2013 Jan 18. 116-21 
PMID: 23072367 [PubMed]
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.
Odegaard, Justin I; Chawla, Ajay
Science (New York, N.Y.). 2013 Jan 11. 172-7 
PMID: 23307735 [PubMed]
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg, Anders; Vigil, Dominico; Zhao, Bin; Daniels, R Nathan; Burke, Jason P; Garcia-Barrantes, Pedro M; Camper, DeMarco; Chauder, Brian A; Lee, Taekyu; Olejniczak, Edward T; Fesik, Stephen W
Journal of medicinal chemistry. 2013 Jan 10. 15-30 
PMID: 23244564 [PubMed]
Probing Enzymatic Activity inside Living Cells Using a Nanowire-Cell "Sandwich" Assay.
Na, Yu-Ran; Kim, So Yeon; Gaublomme, Jellert T; Shalek, Alex K; Jorgolli, Marsela; Park, Hongkun; Yang, Eun Gyeong
Nano letters. 2013 Jan 9. 153-8 
PMID: 23244056 [PubMed]
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.
Amoroso, Mackenzie W; Croft, Gist F; Williams, Damian J; O'Keeffe, Sean; Carrasco, Monica A; Davis, Anne R; Roybon, Laurent; Oakley, Derek H; Maniatis, Tom; Henderson, Christopher E; Wichterle, Hynek
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Jan 9. 574-86 
PMID: 23303937 [PubMed]
Deconvolving the roles of Wnt ligands and receptors in sensing and amplification.
Tan, Rui Zhen; Ji, Ni; Mentink, Remco A; Korswagen, Hendrik C; van Oudenaarden, Alexander
Molecular systems biology. 2013 Jan 8. 631 
PMID: 23295860 [PubMed]
Design and Synthesis of Diverse Functional Kinked Nanowire Structures for Nanoelectronic Bioprobes.
Xu, Lin; Jiang, Zhe; Qing, Quan; Mai, Liqiang; Zhang, Qingjie; Lieber, Charles M
Nano letters. 2013 Jan 7.  
PMID: 23273386 [PubMed]
Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production.
Brynildsen, Mark P; Winkler, Jonathan A; Spina, Catherine S; Macdonald, I Cody; Collins, James J
Nature biotechnology. 2013 Jan 6. 160-5 
PMID: 23292609 [PubMed]
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Division of Program Coordination, Planning, and Strategic Initiatives  •  National Institutes of Health  •  Bethesda, Maryland 20892