Type 1 Diabetes Research - Special Diabetes Program
Type 1 Diabetes-Related Research Resources and Information on Ancillary Studies
Many research consortia and networks supported by the Special Diabetes Program provide resources for use by the scientific community. There are also opportunities for researchers to conduct ancillary studies to ongoing studies. Information on these resources and ancillary studies are described below.
Tissues, Cells, Animal Models |
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| Beta Cell Biology Consortium (BCBC) : The BCBC is facilitating interdisciplinary approaches that will advance understanding of pancreatic islet cell development and function. The long-term scientific goal is to develop a cell-based therapy to restore normal insulin production and action to people with diabetes. Research resources available on the BCBC website include mouse models, mESC lines, antibodies, adenoviruses, genomic studies, data, and protocols.
http://www.betacell.org/  |
| Diabetic Complications Consortium (DCC) : The Animal Models of Diabetic Complications Consortium (AMDCC) has transitioned into the DCC. The DCC will continue to provide a nucleation site for interaction and collaboration among researchers studying diabetes complications. http://www.diacomp.org/ |
| Diabetic Complications Consortium Preclinical Testing Program (DCC-PTP) : The DCC-PTP provides investigators with access to pilot funds to pursue preclinical studies of promising new therapeutics. http://www.diacomp.org/shared/preclinical.aspx |
| Integrated Islet Distribution Program (IIDP) : The IIDP processes and distributes high-quality human cadaveric islets to the diabetes research community for basic research.
http://iidp.coh.org/ |
| Type 1 Diabetes Mouse Resource (T1DR) : The goal of the T1DR is to enhance existing investments in animal models of type 1 diabetes research by facilitating the development and sharing of these unique resources. It provides a source for distribution of mouse strains related to type 1 diabetes and its complications to the scientific community.
http://type1diabetes.jax.org |
Clinical Data |
| Collaborative Islet Transplant Registry (CITR) : CITR is expediting progress and promoting safety in islet/beta cell transplantation through the collection, analysis, and communication of comprehensive and current data on all islet/beta cell transplants performed in North America. Annual reports with data from islet transplant programs are available on the CITR website.
http://www.citregistry.org |
| Diabetes Research in Children Network (DirecNet) : DirecNet is a multicenter clinical research network investigating the use of technology advances in the management of type 1 diabetes in children and adolescents. Study information, protocols, datasets, publications, and slidesets are available on the DirecNet website.
http://direcnet.jaeb.org |
| Diabetic Retinopathy Clinical Research Network (DRCR.net) : The DRCR.net is a collaborative, nationwide network of eye doctors and investigators conducting clinical research of diabetes-induced retinal disorders. Resources posted on the DRCR.net website include datasets, policies, procedures, publications, and presentations.
http://drcrnet.jaeb.org |
| Epidemiology of Diabetes Interventions and Complications (EDIC) : EDIC is studying the clinical course and risk factors associated with the long-term complications of type 1 diabetes, using the cohort of patients who participated in the landmark Diabetes Control and Complications Trial (DCCT). See the NIDDK Central Repositories website for access to DCCT/EDIC resources:
www.niddkrepository.org/niddk/jsp/public/dataset.jsp#EDIC/DCCT http://www2.bsc.gwu.edu/bsc/oneproj.php?pkey=10 |
| NIDDK Central Repositories for Biosamples and Data : The Central Repositories store data and biological samples (including samples for genetic analyses) from significant, NIDDK-funded clinical studies, including several studies focused on type 1 diabetes such as DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications), DPT-1 (Diabetes Prevention Trial-Type 1), GoKinD (The Genetics of Kidneys in Diabetes), and T1DGC (Type 1 Diabetes Genetics Consortium). The purpose of the Central Repositories is to expand the usefulness of these and other NIDDK-supported studies by providing access to the biosamples and data to a wider research community beyond the end of the study. https://www.niddkrepository.org/niddk/home.do |
| Search for Diabetes in Youth (SEARCH ) : The SEARCH multicenter epidemiological study is identifying cases of diabetes in children and youth less than 20 years of age in five geographically dispersed populations that encompass the ethnic diversity of the United States.
http://www.searchfordiabetes.org |
| Type 1 Diabetes Genetics Consortium (T1DGC) : The T1DGC organizes international efforts to identify genes that determine an individual's risk of type 1 diabetes. See the NIDDK Central Repositories website for access to T1DGC resources: www.niddkrepository.org/niddk/jsp/public/dataset.jsp#T1DGC
https://www.t1dgc.org/home.cfm |
Biosamples and Opportunities for Ancillary Studies |
| Biosamples from several type 1 diabetes studies are stored at the NIDDK Central Repositories at https://www.niddkrepository.org/niddk/jsp/public/diabetes.jsp . Additionally, investigators interested in pursuing ancillary studies of ongoing studies are invited to contact the studies directly. For a list of ongoing clinical studies, please see Research Consortia and Clinical Trials Networks.
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| Epidemiology of Diabetes Interventions and Complications (EDIC) : EDIC is studying the clinical course and risk factors associated with the long-term complications of type 1 diabetes, using the cohort of patients who participated in the landmark Diabetes Control and Complications Trial (DCCT). See the NIDDK Central Repositories website for access to DCCT/EDIC resources:
www.niddkrepository.org/niddk/jsp/public/dataset.jsp#EDIC/DCCT http://www2.bsc.gwu.edu/bsc/oneproj.php?pkey=10 |
| NIDDK Central Repositories for Biosamples and Data : The Central Repositories store data and biological samples (including samples for genetic analyses) from significant, NIDDK-funded clinical studies, including several studies focused on type 1 diabetes such as DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications), DPT-1 (Diabetes Prevention Trial-Type 1), GoKinD (The Genetics of Kidneys in Diabetes), and T1DGC (Type 1 Diabetes Genetics Consortium). The purpose of the Central Repositories is to expand the usefulness of these and other NIDDK-supported studies by providing access to the biosamples and data to a wider research community beyond the end of the study. https://www.niddkrepository.org/niddk/home.do |
| Research Funding for Ancillary Studies (Ancillary Studies) : Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (PAR-09-247) This Funding Opportunity Announcement encourages Research Project Grant (R01) applications from qualified investigators to conduct ancillary studies to major ongoing clinical research studies, including several funded by the Special Diabetes Program: Type 1 Diabetes TrialNet , Epidemiology of Diabetes Interventions and Complications Study (EDIC) , The Environmental Determinants of Diabetes in the Young (TEDDY) , and SEARCH for Diabetes in Youth . For more information, see: www2.niddk.nih.gov/Research/ClinicalResearch/AncillaryStudies |
| Type 1 Diabetes Genetics Consortium (T1DGC) : The T1DGC organizes international efforts to identify genes that determine an individual's risk of type 1 diabetes. See the NIDDK Central Repositories website for access to T1DGC resources: www.niddkrepository.org/niddk/jsp/public/dataset.jsp#T1DGC
https://www.t1dgc.org/home.cfm |
Centers |
| Diabetes Research Centers (Diabetes Research Centers) : Diabetes Research Centers support and enhance the national research effort in diabetes and related endocrine and metabolic diseases. Diabetes Research Centers support three primary research-related activities: Research Core services, a Pilot and Feasibility (P&F) program, and an Enrichment program. More information on research resources available through the Diabetes Research Centers is available at: http://www.diabetescenters.org/ |
| Mouse Metabolic Phenotyping Centers (MMPCs) : The MMPCs provide the scientific community with standardized, high-quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders. Using state-of-the-art technology and on a fee-for service basis, the MMPCs provide a range of complex exams used to characterize mouse metabolism, blood composition including hormones, energy balance and physical activity, eating and exercise, insulin resistance, organ function, metabolic fluxes and morphology, physiology, histology, and measures of diabetic complications in heart, kidney, vasculature, eye, and other tissues and organs.
http://www.mmpc.org/ |
Pre-clinical Development Services for Therapeutic Agents |
| Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID) : T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of novel, scientifically meritorious therapeutic interventions for type 1 diabetes and its complications. T1D-RAID is not a grant mechanism and it does not sponsor clinical trials; approved requests to T1D-RAID gain access to drug development resources. http://t1diabetes.nih.gov/T1D-RAID/ |
Last Updated: 05/15/2012
