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(75) Publications in 2010

Burnham

  1. Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles. Herath, A., Dahl, R., Cosford, N. Org Lett., 2010, 12(3): 412-5.
  2. Design and synthesis of selective inhibitors of Placental Alkaline Phosphatase. Lanier, M., Sergienko, E., Simão, A.M., Su, Y., Chung, T., Millán, J.L., Cashman, J.R. Bioorg Med Chem., 2010, 18(2): 573-579.

Hopkins

  1. Organelle-specific, rapid induction of molecular activities and membrane tethering. Komatsu, T., Kukelyansky, I., McCaffery, J.M., Ueno, T., Varela, L.C., Inoue, T. Nature Methods, 2010, 7:206-208.

Kansas

  1. Application of Kernel Functions for Accurate Similarity Search in Large Chemical Databases. Xiaohong Wang, Jun Huan, Aaron Smalter, Gerald H. Lushington, BMC Bioinformatics, 2010, Vol. 11 (Suppl 3): S8, 2010.
  2. Uptake, Distribution and Diffusivity of Reactive Fluorophores in Cells: Implications toward Target Identification. Christopher W. Cunningham, Archana Mukhopadhyay, Gerald H. Lushington, Brian S. J. Blagg, Thomas E. Prisinzano and Jeffrey P. Krise, Mol. Pharmaceutics, 2010, 7 (4), pp 1301-1310

NCGC

  1. A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety. Boxer, M.B., Quinn, A.M., Shen, M., Jadhav, A., Leister, W., Simeonov, A., Auld, D.S., Thomas, C.J. ChemMedChem., 2010, 5(5):730-738.
  2. Evaluation of Substituted N,N0-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase. Boxer, M.B., Jiang, J.K., Vander Heiden, M.G., Shen, M., Skoumbourdis, A.P., Southall, N.T., Veith, H., Leister, W., Austin, C.P., Park, H.W., Inglese, J., Cantley, L.C., Auld, D.S., Thomas, C.J. J. Med. Chem., 2010, 53:1048–1055.
  3. Chronic active B-cell-receptor signalling in diffuse large Bcell lymphoma. Davis, R.E., Ngo, V.N., Lenz, G., Tolar, P., Young, R.M., Romesser, P.B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., Xu,W., Shaffer, A.L., Wright, G., Xiao, W., Powell, J., Jiang, J-, Thomas, C.J., Rosenwald, A., Ott, G., Muller-Hermelink, H.K., Gascoyne, R.D., Connors, J.M., Johnson, N.A., Rimsza, L.M., Campo, E., Jaffe, E.S., Wilson, W.H., Delabie, J., Smeland, E.B., Fisher, R.I., Braziel, R.M., Tubbs, R.R., Cook, J.R., Weisenburger, D.D., Chan, W.C., Pierce, S.K., Staudt, L.M. Nature, 2010, 463(7277):88-92.
  4. Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease. Jadhav, A., Ferreira, R.S., Klumpp, C., Mott, B.T., Austin, C.P., Inglese, J., Thomas, C.J., Maloney, D.J., Shoichet, B.K., Simeonov, A. J. Med. Chem., 2010, 53(1), 37-51.
  5. Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase. Part 2: Substituted Thieno[3,2-b]pyrrole[3,2-d]pyridazinones. Jiang, J.-K., Boxer, M.B., Vander Heiden, M.G., Shen, M., Skoumbourdis, A.P., Southall, N., Veith, H., Leister, W., Austin, C.P., Park, H.W., Inglese, J., Cantley, L.C., Auld, D.S., Thomas, C.J. J. Med. Chem., 2010, 53(3): 1048–1055
  6. A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists. Liu, K., Southall, N., Titus, S.A., Inglese, J., Eskay, R.L., Shinn, P., Austin, C.P., Heilig, M.A., Zheng, W. Assay Drug Dev Technol., 2010, 8(3): 367-379.
  7. Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. Marugan, J.J., Zheng, W., Motabar, O., Southall, N., Goldin, E., Sidransky, E., Aungst, R.A., Liu, K., Sadhukhan, S.K., Austin, C.P. Eur J Med Chem., 2010, 45(5):1880-1897.
  8. Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Miller, S.C., Huang, R., Sakamuru, S., Shukla, S.J., Attene-Ramos, M.S. Shinn, P., Van Leer, D., Leister, W., Austin, C.P., Xia, M. Biochem Pharmacol, 2010, 79:1272-1280.
  9. Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB. Mott, B.T., Ferreira, R.S., Simeonov, A., Jadhav, A., Ang, KK-H., Leister, W., Shen, M., Silveira, J.T., Doyle, P.S., Arkin, M.R., McKerrow, J.H., Inglese, J., Austin, C.P., Thomas, C.J., Shoichet, B.K., Maloney, D.J. Journal of Medicinal Chemistry, 2010, 53(1), 52- 60.
  10. A Chemiluminescence-based Method for Identification of Histone Lysine Methyltransferase Inhibitors. Quinn, A., Allali-Hassani, A., Vedadi, M., Simeonov, Molecular BioSystems, 2010, 6(5): 782-788.
  11. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Quinn, A.M., Bedford, M.T., Espejo, A., Spannhoff, A., Austin, C.P., Oppermann, U., Simeonov, A. Nucleic Acids Res., 2010, 38(2):e11.
  12. A miniaturized screen for inhibitors of Jumonji histone demethylases. Sakurai, M., Rose, N.R., Schultz, L., Quinn, A.M., Jadhav, A., Ng, S.S., Oppermann, U., Schofield, C.J., Simeonov, A. Mol Biosyst., 2010, 6(2):357-64.
  13. A Strategy to Discover Inhibitors of Bacillus subtilis Surfactin-type Phosphopantetheinyl Transferase. Yasgar, A., Foley, T., Jadhav, A., Inglese, J., Burkart, M., Simeonov, A. Mol. BioSyst., 2010, 6(2): 365-375.
  14. A High- Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity.Yasgar, A., Shultz, J., Zhou, W., Wang, H., Huang, F., Murphy, N., Abel, E.L., DiGiovanni, J., Inglese, J., Simeonov, A. ASSAY and Drug Development Technologies,2010, 8(2): 200-211.
  15. A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC. Endocrinology. 2010 Jul;151(7):3454-9. Epub 2010 Apr 28.
  16. Apparent activity in high-throughput screening: origins of compound-dependent assay interference. Thorne N, Auld DS, Inglese J. Curr Opin Chem Biol. 2010 Jun;14(3):315-24.” Epub 2010 Apr 22.
  17. Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix  Environ Sci Technol. 2010 Aug 1;44(15):5979-85.
  18. Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines As Antagonists of the Neuropeptide S Receptor. McCoy JG, Marugan JJ, Liu K, Zheng W, Southall N, Huang W, Heilig M, Austin CP. ACS Chem. Neurosci., 2010, 1 (8), pp 559-574
  19. Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57.
  20. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. J Med Chem. 2010 Jul 8;53(13):4891-905.
  21. Preparation of FRET reporters to support chemical probe development. Foley TL, Yasgar A, Garcia CJ, Jadhav A, Simeonov A, Burkart MD. Org Biomol Chem. 2010 Oct 21;8(20):4601-6.
  22. Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1. Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. J Med Chem. 2010 Sep 24.
  23. Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology. Thorne N, Inglese J, Auld DS. Chem Biol. 2010 Jun 25;17(6):646-57
  24. The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Shukla SJ, Huang R, Austin CP, Xia M. Drug Discov Today. 2010 Aug 11
  25. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH. Cancer Res. 2010 Jun 1;70(11):4509-19
  26. Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009. Dolle RE, Bourdonnec BL, Worm K, Morales GA, Thomas CJ, Zhang W. J Comb Chem. 2010 Oct 5.
  27. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Feng J, Petersen CD, Coy DH, Jiang JK, Thomas CJ, Pollak MR, Wank SA. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17791-6.

New Mexico

  1. Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Arterburn, J.B., Oprea, T.I., Prossnitz, E.R., Edwards, B.S., Sklar, L.A. Current Topics in Medicinal Chemistry, 2010, 9:1227-36.
  2. Real-time partitioning of octadecyl rhodamine B into bead-supported lipid bilayer membranes revealing quantitative differences in saturable binding sites in DOPC and 1:1:1 DOPC/SM/cholesterol membranes. Buranda T, Wu Y, Perez D, Chigaev A, Sklar LA. Journal of Physical Chemistry B, 2010, 114:1336-49.
  3. iPHACE: integrative navigation in pharmacological space. Garcia-Serna, R., Ursu, O., Oprea, T.I., Mestres, J. Bioinformatics, 2010, Feb 15. [Epub]
  4. Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Johnson, R.M., Allen, C., Melman, S.D., Waller, A., Young, S.M., Sklar, L.A., Parra, K.J. Analytical Biochemistry, 2010, 398:203-11.
  5. Conformational mAb as a tool for integrin ligand discovery. Njus, B.H., Chigaev, A., Waller, A., Wlodek, D., Ostopovici-Halip, L., Ursu, O., Wang, W., Oprea, T.I., Bologa, C.G., Sklar, L.A. Assay and Drug Development Technologies, 2010, 7:507-15.
  6. Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. Ramesh, C., Nayak, T.K., Burai, R., Dennis, M.K., Hathaway, H.J., Sklar, L.A., Prossnitz, E.R., Arterburn, J.B. Journal of Medicinal Chemistry, 2010, 53:1004-1014.
  7. High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. Saunders MJ, Graves SW, Sklar LA, Oprea TI, Edwards BS. Assay and Drug Development Technologies, 2010, 8:37-46.
  8. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. Surviladze, Z., Waller, A., Wu, Y., Romero, E., Edwards, B.S., Wandinger-Ness, A., Sklar, L.A. Journal of Biomolecular Screening, 2010, 15:10­20.
  9. Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111 in-labelled nonsteroidal imaging agents. Nayak TK, Dennis MK, Ramesh C, Burai R, Atcher RW, Sklar LA, Norenberg JP, Hathaway HJ, Arterburn JB, Prossnitz ER. ACS Chem Biol. 2010 Jul 16; 5:681-90.
  10. Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Burai R, Ramesh C, Shorty M, Curpan R, Bologa C, Sklar LA, Oprea T, Prossnitz ER, Arterburn JB. Org Biomol Chem. 2010 May 7;8(9):2252-9.
  11. The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, Black MA, Donato AL, Arterburn JB, Oprea TI, Prossnitz ER, Dun NJ, Jordan VC. Cancer Res. 2010 Feb 1;70(3):1184-94.
  12. Model-free drug-likeness from fragments. Ursu O, Oprea T. J Chem Inf Model. 2010 Aug 23;50(8):1387-94.

Penn

  1. Identification of novel inhibitors of dietary lipid absorption using zebrafish. Clifton J.D., Lucumi E., Myers M.C., Napper A., Hama K., Farber S.A., Smith A.B. 3rd, Huryn D.M., Diamond S.L., & Pack M. PLoS One. 2010, 5(8):e12386.
  2. A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Shah P.P., Wang T., Kaletsky R.L., Myers M.C., Purvis J.E., Jing H., Huryn D.M., Greenbaum D.C., Smith A.B. 3rd, Bates P., & Diamond S.L. Mol Pharmacol. 2010, 78(2):319-24.
  3. Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. Liu Z., Myers M.C., Shah P.P., Beavers M.P., Benedetti P.A., Diamond S.L., Smith A.B. 3rd, & Huryn D.M. Comb Chem High Throughput Screen. 2010, 13(4):337-51.
  4. Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Sivendran S., Jones V., Sun D., Wang Y., Grzegorzewicz A.E., Scherman M.S., Napper A.D., McCammon J.A., Lee R.E., Diamond S.L., & McNeil M. Bioorg Med Chem. 2010, 18(2):896-908.

Scripps

  1. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). Bachovchin, D.A., Wolfe, M.R., Masuda, K., Brown, S.J., Spicer, T.P., Fernandez-Vega, V., Chase, P., Hodder, P.S., Rosen, H., Cravatt, B.F. Bioorg Med Chem Lett. 2010, 20(7): 2254-2258.
  2. A High-Throughput-Screening-Compatible Assay for Activators and Inhibitors of Methionine Sulfoxide Reductase A. Brunell, D., Weissbach, H., Hodder, P., Brot, N. Assay Drug Dev Technol. 2010.
  3. Small activators reveal that TRPML3 integrates multiple stimulation modes. Grimm, C., Jörs, S., Saldanha, A., Obukhov, A.G., Pan, B., Oshima, K., Cuajungco, M.P., Chase, P., Hodder, P., Heller, S. Chem Biol. 2010,17(2):135-148.
  4. A Time-Resolved Fluorescence-Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization. Kota, S., Scampavia, L., Spicer, T., Beeler, A.B., Takahashi, V., Snyder, J.K., Porco, J.A. Jr, Hodder, P., Strosberg, A.D. Assay Drug Dev Technol. 2010, 8(1):96-105.
  5. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. Walsh, K.B., Marsolais, D., Welch, M.J., Rosen, H., Oldstone, M.B. Virology., 2010, 397(2):260-269.
  6. Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. Wang, Y., Kumar, N., Solt, L.A., Richardson, T.I., Helvering, L.M., Crumbley, C., Garcia-Ordonez, R.A., Stayrook, K.R., Zhang, X., Novick, S., Chalmers, M.J., Griffin, P.R., Burris, T.P. J Biol Chem. 2010, 285(7): 5013-1525.
  7. A Second Class of Nuclear Receptors for Oxysterols: Regulation of RORalpha and RORgamma activity by 24S-Hydroxycholesterol. Wang, Y., Kumar, N., Crumbley, C., Griffin, P., Burris, T.P. BBA -Molecular and Cell Biology of Lipids., 1801(8): 917-923.
  8. Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange.Zhang, X., Chien, E.Y., Chalmers, M.J., Pascal, B.D., Gatchalian, J., Stevens, R.C., Griffin, P.R. Anal Chem. 2010, 82(3):1100-1108.
  9. Methods for the analysis of high precision differential hydrogen-deuterium exchange data. Chalmers M.J., Pascal B.D., Willis S., Zhanga J., Iturria S.J., Dodge J.A., and Griffin P.R. Int. J. MassSpectrom. 2010.
  10. A fluopol-ABPP HTS assay to identify PAD inhibitors. Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. Chem Commun. 2010 Oct 14; 46(38):7175-7.
  11. Identification of a Synthetic Agonist for the Orphan Nuclear Receptors RORalpha and RORgamma, SR1078.Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, Roush WR, Griffin PR, Burris TP. ACS Chem Biol. 2010 Aug 30.
  12. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.Gianni D, Taulet N, Zhang H, Dermardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch G, Rosen H. ACS Chem Biol. 2010 Oct 15;5(10):981-93.
  13. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARc by Cdk5. Jang Hyun Choi, Alexander S. Banks, Jennifer L. Estall1, Shingo Kajimura1, Pontus Bostrom, Dina Laznik, Jorge L. Ruas, Michael J. Chalmers, Theodore M. Kamenecka, Matthias Bluher, Patrick R. Griffin & Bruce M. Spiegelman. Nature. 2010 Jul 22;466(7305):451-6.
  14. NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-beta-Lactamase: Synthesis and Structure-Activity Studies. Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV. ACS Med Chem Lett. 2010 Jul 8;1(4):150-154.
  15. Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.Solt LA, Griffin PR, Burris TP. Curr Opin Lipidol. 2010 Jun;21(3):204-11.
  16. A High-Throughput Screening Compatible Assay for Activators and Inhibitors of Methionine Sulfoxide Reductase A.Brunell D, Weissbach H, Hodder P, Brot N. Assay Drug Dev Technol. 2010 Jun 1.
  17. Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands.Kumar N., Solt L.A., Wang Y., Rogers P.M., Bhattacharyya G., Kamenecka T.M., Stayrook K.R., Crumbley C., Floyd Z.E., Gimble J.M., Griffin P.R., and Burris T.P. Endocrinology. 2010 Jul; 151(7):3015-25.
  18. Small Molecule Activators of TRPML3.Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S. Chem Biol. 2010 Feb 26; 17(2):135-48.
  19. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Wang Y, Kumar N, Crumbley C, Griffin PR, Burris TP. Biochim Biophys Acta. 2010 Aug; 1801(8):917-23.
  20. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization.Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. Assay Drug Dev Technol. 2010 Feb;8(1):96-105.
  21. Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.Wang Y, Kumar N, Solt LA, Richardson TI, Helvering LM, Crumbley C, Garcia-Ordonez RD, Stayrook KR, Zhang X, Novick S, Chalmers MJ, Griffin PR, Burris TP. J Biol Chem. 2010 Feb 12;285(7):5013-25.
  22. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2254-8.
  23. The benzenesulfonamide T0901317 is a novel RORa/g Inverse Agonist.Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez R, Burris TP, Griffin PR. Mol Pharmacol. 2010 Feb;77(2):228-36.
  24. Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High Throughput Screening. Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS.Mol Pharmacol. 2010 Jan;77(1):46-57.
  25. Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles. Noël R, Song X, Jiang R, Chalmers MJ, Griffin PR, Kamenecka TM.J Org Chem. 2009 Oct 2;74(19):7595-7.

Southern Research Institute

  1. HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity. Chung, D.H., Jonsson, C.B., Maddox, C., McKellip, S.N., Moore, B.P., Heli, M., White, E.L., Ananthan, S., Li, Q., Feng, S., Rasmussen, L. Molecules, 2010, 15(3): 1690-1704.

Vanderbilt

  1. Differential effects of allosteric M1 muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation Davis, A.A.; Heilman, C.J.; Brady, A.E.; Miller, N.R.; Fuerstenau-Sharpo, M.; Hanson, B.J.;  Lindsley, C.W.; Conn, P.J.; Lah, J.J.; Levey, A.I.  ACS Chem. Neurosci. 2010, 1, 542-551.
  2. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGluR4 PAMs identified by functional HTS. Engers, D.W.; Gentry, P.R.; Williams, R.; Bolinger, D.L.; Weaver, C.D.; Menon, U.N.; Conn, P.J.  Lindsley, C.W.; Niswender, C.M.; Hopkins, C.R. Bioorg. Med. Chem. Lett. 2010, 20, 5175-5178
  3. Synthesis of 2,3-diarylsubstituted indazole utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence. Salovich, J.A.; Lindsley, C.W.; Hopkins, C.R. Tetrahedron Lett. 2010, 51, 3796-3799.
  4. Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel. Gautam Bhave, Brian A. Chauder, Wen Liu, Eric S. Dawson, Rishin Kadakia, Thuy, T. Nguyen, L. Michelle Lewis, Jens Meiler, C. David Weaver, Lisa M. Satlin, Craig W. Lindsley, and Jerod S. Denton. Mol. Pharmacol. 2010, asap article.
  5. Small-Molecule Modulators of Inward Rectifier Potassium Channels: Recent Advances and Future Possibilities.  Gautam Bhave, Daniel Lonergan, Brian A. Chauder and Jerod S. Denton.  Future Med. Chem. 2010, 2, 757-774.