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Database Version:1.4 |  |
| Home | NCI-60 Analysis Tools | Query Genomic Data | Query Drug Data | Download Data Sets | Cell Line Metadata | Data Set Metadata | Mutation Data |
CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990).
To cite the tool, the primary literature references is (Reinhold, Cancer Res, 2012).
Press articles reviewing CellMiner may be accessed here (Cancer Discovery) (CCR Connections) (Slashdot) (NCI press release) (FierceBiotechIT).
Additional references: (Liu, Mol Cancer Ther, 2010), (Shankavarum, BMC Genomics, 2009), and the URL is http://discover.nci.nih.gov/cellminer.
Subsequent builds will include additional molecular data sets and integrative capabilities.
How to find the information you need in CellMiner
- For DNA, RNA or Protein data use the:
- NCI-60 Analysis Tools tab to access automation of several commonly done analyses (Reinhold, Cancer Res, 2012).
- Query Genomic Data tab to query the normalized data sets for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
- Data Set Metadata tab to get background information about each data set.
- Download Data Sets tab to download the entire data set, in either raw or normalized versions.
- For drug data use the:
- NCI-60 Analysis Tools tab to access automation of several commonly done analyses (Reinhold, Cancer Res, 2012).
- Query Drug Data tab to query the drug data for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
- Data Set Metadata tab to get details about the different drug datasets.
- Download Data Sets tab to download the entire data set, in either raw or normalized versions.
- For cell line information use the:
- Cell Line Metadata tab to view metadata on the NCI-60 panel. Included are tissue type, patient demographics, prior treatment, histology, source, ploidy, p53 status, DNA fingerprint data, etc.
- For Sequence Mutation with analysis for 24 genes use the:
- Mutation Data tab to get a list of mutations found in 24 known, important human cancer genes.
| Links | |
| For other bioinformatic tools and database resources from GBG go to the Discover website home page. | |
| For additional drug, dataset and molecular target data see the NCI Developmental Therapeutics Program site. | |
CellMiner Development Team
Margot Sunshine, Sudhir Varma, William Reinhold and Yves Pommier prior contributors
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CellMiner™ is a development of the Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology (LMP), Center for Cancer Research (CCR), National Cancer Institute (NCI). Please email us with any problems, questions or feedback on the tool.