Access MLPCN Resources
SubMenus: MLPCN Centers | Center Capabilities | Technical Assistance | Documents & Definitions
The MLPCN resource can be accessed by any member of the scientific community in a number of ways,
If you already have an HTS-ready assay (in 96, 384, 1536-well plate or flow cytometry) you can:
- Obtain technical assistance in developing a high throughput screening (HTS) plan by clicking here
- Apply through R03 Assay Implementation for peer review organized by CSR **This announcement has expired**
- Apply through “Solicitation of Assays for High Throughput Screening (HTS) to Discover Chemical Probes” R01 and R21 funding opportunities.
If you have a potentially HTS-compatible assay (in test tube or 96-well plate) you can:
- Obtain technical assistance in developing a high throughput screening (HTS) plan by clicking here
- Apply through R21 Assay Development for peer review organized by CSR **This announcement has expired**
- Apply through R21/R33 Neurobiological Assay Development for projects relevant to neurobiological processes and pathways
If you have a validated screening hit eligible for development into an in vivo chemical probe you can:
Apply through “Solicitation of Validated Hits for the Discovery of in vivo Chemical Probes” R01 funding opportunity
If you are a PI of an existing assay grant (R21, R01 etc) you can:
- Obtain technical assistance in developing a high throughput screening (HTS) plan by clicking here.
- Fast Track Entry of Assay Projects Apply for Fast Track entry to MLPCN click: Fast Track Entry Request.
- Fast Track Entry of Medicinal Chemistry Projects Please contact Enrique Michelotti (michelottiel@mail.nih.gov) prior to completing the application, found here: Chemistry Fast Track Template (September 2010).
If you wish to submit compounds to the Molecular Libraries Small Molecule Repository you can:
Find guidance for compound submission here
Contact Jamie Driscoll
Benefits of using the MLPCN for an assay provider?
There are a number of benefits to using the MLPCN for your small molecule bioassays. Some of these are highlighted below:
- In collaboration with an MLPCN center you can get a small molecule probe with characteristics specified in the grant proposal. This includes the primary HTS screen and follow-up cheminformatics/informatics and medicinal chemistry.
- This is possible with completely free or minimal costs to the assay provider.
- Get free access to one of the largest academic screening collections around. The small molecule collection includes the (possibly) largest publicly available collection of known bioactives, a range of novel chemical classes sourced from the academic community, and a diverse set of commercially available compounds.
- The network of MLPCN centers have a broad range of expertise in different assay types and formats and scientific expertise in a range of disease biology.
