About Us
Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.
Recent Publications
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A systems approach to the biology of mood disorders through network analysis of candidate genes. Detera-Wadleigh SD & Akula N;. Pharmacopsychiatr. 2011, 44 (Suppl 1): S35-42.
A network-based approach to prioritize results from genome-wide association studies. Akula N, Baranova A, Seto D, Solka J, Nalls MA, Singleton A, Ferrucci L, Tanaka T, Bandinelli S, Cho YS, Kim YJ, Lee JY, Han BG; Bipolar Disorder Genome Study (BiGS) Consortium; Wellcome Trust Case-Control Consortium, McMahon FJ. PLoS One. 2011;6(9):e24220. Epub 2011 Sep 6.
The genetics of panic disorder. Schumacher J, Kristensen AS, Wendland JR, Nöthen MM, Mors O, McMahon FJ. J Med Genet. 2011 Jun;48(6):361-8. doi: 10.1136/jmg.2010.086876. Epub 2011 Apr 14. Review.
A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study. Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. Mol Psychiatry. 2011 Jun;16(6):584-5. doi: 10.1038/mp.2011.1. Epub 2011 Feb 22.
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD, Steele CJ, Breuer R, Strohmaier J, Wendland JR, Mattheisen M, Mühleisen TW, Maier W, Nöthen MM, Cichon S, Farmer A, Vincent JB, Holsboer F, Preisig M, Rietschel M; Bipolar Disorder Genome Study (BiGS) Consortium. Nat Genet. 2010 Feb;42(2):128-31. Epub 2010 Jan 17.
A genome-wide association study of amygdala activation in youths with and without bipolar disorder. Liu X, Akula N, Skup M, Brotman MA, Leibenluft E, McMahon FJ. J Am Acad Child Adolesc Psychiatry. 2010 Jan;49(1):33-41.
Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Laje G, Perlis RH, Rush AJ, McMahon FJ. Psychiatr Serv. 2009 Nov;60(11):1446-57.
Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. Gupta A, Schulze TG, Nagarajan V, Akula N, Corona W, Jiang XY, Hunter N, McMahon FJ, Detera-Wadleigh SD. Pharmacogenomics J. 2011 Mar 8. [Epub ahead of print]
Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ. Int J Neuropsychopharmacol. 2010 Jul;13(6):715-24. Epub 2010 Jan 5.
Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Laje G, Allen AS, Akula N, Manji H, John Rush A, McMahon FJ. Pharmacogenet Genomics. 2009 Sep;19(9):666-74.
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Schulze TG, Detera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nöthen MM, Cichon S, Schumacher J; NIMH Genetics Initiative Bipolar Disorder Consortium, Rietschel M, McMahon FJ. Mol Psychiatry. 2009 May;14(5):487-91. Epub 2008 Dec 16.