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RNA Regulation Section |
| Biography: Dr. Gorospe received her Ph.D. in Molecular and Developmental Biology from the State University of New York at Albany in 1993. She then joined the National Institute on Aging (NIA) for post-doctoral training and has been a Principal Investigator and head of the RNA Regulation Section since 1998. Her group studies post-transcriptional gene regulation in mammalian models of cellular stress, cell division, senescence, and aging. Her research program investigates the influence of RNA-binding proteins (RBPs) and microRNAs on the expression of gene products involved in these processes. | |
| RNA sequences modulate turnover and translation of mammalian mRNAs: RBPs and microRNAs associate dynamically with mRNAs and modulate their stability and translation rates. We use human diploid fibroblasts and immortal human cell lines to study specific mRNAs encoding proteins involved in cell division, cellular senescence, and the response to cellular damage (e.g., cdks, cyclins, cdk inhibitors, apoptosis-related proteins, oncoproteins, and tumor suppressors). We study the 5’-untranslated region (UTR), the coding region (CR) and the 3’UTR of mRNAs to identify sequences that affect mRNA half-life and translation, such as regions of association with RBPs and sequences of interaction with microRNAs. | |
| mRNA-binding factors control mRNA turnover and translation: RBPs and microRNAs regulate subsets of mRNAs in cells responding to injury and mitogens. By performing these functions, RBPs and microRNAs orchestrate gene expression programs associated with senescence and aging. We are interested in identifying collections of target mRNAs for RBPs and microRNAs using a variety of high-throughput methods. We also aim to uncover the processes that regulate RBP levels, localization, and activity, as well as the molecular processes that affect microRNA expression and function. We are particularly interested in understanding the joint influence of RBPs and microRNAs on shared target transcripts. | |
| Influence of mRNA turnover and translation on age-related processes: By influencing mRNA metabolism, RBPs and microRNAs can coordinate the expression of genes in specific biological processes. A major initiative in our laboratory is to investigate how ribonucleoprotein (RNP) associations orchestrate the cell division cycle, apoptosis, replicative senescence, differentiation, and the stress response. By affecting these cellular processes, we seek to gain insight into age-related diseases such as cancer, diabetes, obesity, and neurodegeneration. | |
| PubMed: Search for listing of Dr. Gorospe's publications. | |
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RNA Regulation Section Back row (Left to right) : Kotb Abdelmohsen; Je-Hyun Yoon; Amaresh Panda; Yannis Grammatikakis; Roza Selimyan Front row (Left to right) : Kumiko Tominaga; Lynn Wu; Myriam Gorospe; Jennifer Martindale |
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