National Cancer Institute U.S. National Institutes of Health www.cancer.gov
Cancer Diagnosis Program (CDP)
CDP Tissue Microarrays

Data Manual for Colon Tissue Microarrays

Data variable Description: Coding: Data Available
Cancer Patient Divertic Patient Polyp Patient
StudyID Designates a specific specimen nnnnnnn - 7-digit ID X X X
TissueSource Identifies source (type) of tissue 10=Colon Cancer
20=Normal tissue from diverticulitis patient
30=Normal tissue from cancer patient (matched)
40=Adenomatous colon polyp from patient with no evidence of cancer 		X X X
Race Race of patient 1=White
2=Black
3=American Indian
4=Asian
5=Pacific Islander
8=Other
9=Unknown
 X X  
Gender Gender of patient 1=Male
2=Female
8=Other
9=Unknown 		X X X
DxAge Age at diagnosis YYY X X X
DxYear Year of diagnosis YYYY X X X
NodesEx Nodes examined xx < 99 is Number of nodes examined
99=Unknown 		X    
NodesPos Nodes positive 0=No nodes positive among those examined
0 < xx < 98 is Number of positive nodes
98=No nodes examined
99=Unknown 		X    
ProximalMarginInv Proximal margin involvement 1=Cannot be assessed
2=Uninvolved by tumor
3=Involved by tumor 		X    
DistalMarginInv Distal margin involvement 1=Cannot be assessed
2=Uninvolved by tumor
3=Involved by tumor 		X    
TStage AJCC (vers. 5) T stage 1=TX Primary tumor cannot be assessed
2=T0 No evidence of primary tumor
3=Tis Carcinoma in situ
4=T1 Tumor invades sub mucosa
5=T2 Tumor invades muscularis propria
6=T3 Tumor invades thru muscularis propria into subserosa, nonperitonealized pericolic or perirectal tissue
7=T4 Tumor directly invades other organs, structures and/or perforates visceral peritoneum 		X    
NStage AJCC (vers. 5) N stage 1=NX Regional lymph nodes cannot be assessed
2=N0 No regional lymph node metastasis
3=N1 Metastasis in one to three regional lymph nodes
4=N2 Metastasis in four or more regional lymph nodes 		X    
MStage AJCC (vers. 5) M stage 1=MX Presence of distant metastasis cannot be assessed
2=M0 No distant metastasis
3=M1 Distant metastasis 		X    
SummaryStage AJCC (vers. 5) overall stage
Stage Dukes
1=I T1 N0 M0 A
  T2 N0 M0 A
2=II T3 N0 M0 B
  T4 N0 M0 B
3=III Any T N1 M0 C
  Any T N2 M0 C
4=IV Any T Any N M1 C
X    
Histology Histology of tissue 1=Adenocarcinoma
2=Mucinous adenocarcinoma (colloid type; > 50% mucinous adenocarcinoma) 3=Signet ring cell carcinoma (> 50% signet ring cell)
4=Medullary carcinoma
5=Undifferentiated carcinoma
6=Carcinoma, NOS
7=Other 		X    
HistologyGrade Histology grade of tissue 1=GX Grade cannot be assessed
2=G1 Well differentiated
3=G2 Moderately differentiated
4=G3 Poorly differentiated
5=G4 Undifferentiated
NOTE:
G1 & G2 =low grade and G3 & G4=high grade 		X    
Location Location of cancer 1=Right (ascending) colon
2=Hepatic flexure
3=Transverse colon
4=Splenic flexure
5=Left (descending) colon
6=Rectosigmoid junction
7=Cecum
8=Appendix
9=Sigmoid colon
10=Overlapping lesion
11=Colon, NOS 		X    
VascularInv Blood/lymphatic vessel invasion 1=Intramural vessel
2=Extramural vessel
3=Absent
9=Cannot be assessed 		X    
VitalStatus Vital status at last follow-up 1=Alive
2=Deceased		 X    
TimeToDeath Time to death or length of time verified alive Months
Length of time (in months) from date of cancer diagnosis to death or last verified alive 		X    
Recurrence Did patient have a recurrence? 0=No
1=Yes
If MStage=3, then Recurrence=0 and TimeToRecur=NA 		X    
TimeToRecur Time to recurrence or length of time verified recurrence free Months
Length of time (in months) from date of cancer diagnosis to first recurrence or last verified recurrence free 		X    
Typeoffirstrec Type of first recurrence 0=None
10=Local
20=Regional
30=Any combination of 10 and 20
40=Distant
70=Never disease free
88=Recurred, but site unknown 		X    
LastFolup Cancer status at last follow-up 1=Alive:No evidence of this cancer
2=Alive:Never free of this cancer
3=Alive:With persisting recurrence
5=Alive:Status of cancer unknown
6=Dead:No evidence of this ca at death
7=Dead:This ca present, not primary cause
8=Dead:This ca primary cause
10=Dead:Unknown if this ca the primary cause		 X    
Chemotherapy Chemotherapy 0=No 1=Yes X    
RadiationTherapy Radiation therapy 0=No 1=Yes X    
Surgery Was patient treated with surgery? 0=No 1=Yes X    
SurgerytoChemo Time from surgery to chemotherapy Days from surgery to start of chemotherapy X    
SurgerytoRadiation Time from surgery to radiation Days from surgery to start of radiation therapy X    
Subgroup Recurrence subgroup a=Recurred <= 5 years after diagnosis
b=Followed and not recurred within 5 years of diagnosis
c=Not recurred but not followed a minimum of 5 years 		X    
AssociatedCancer Case Cancer case that this normal tissue is associated with Study ID of cancer case from which associated normal tissue was selected (applies only to normal tissue matched to cancer case)      
Adenpolyp Type of adenomatous polyp 1=Tubular adenoma
2=Tubulovillous adenoma
3=Villous adenoma
4=Other adenomatous polyp
5=Mixed hyperplastic and adenomatous		     X
Dysplasia Dysplasia of polyp 1=High
2=Low
3=Absent		     X
Grosssize Gross size of largest polyp Greatest dimension in millimeters
99=size not determined 		    X
Comments Comments Text
Any special clinical, pathologic, or specimen information concerning this case that is not captured in the standard data fields 		X X X