The CDP 2008 Series Stage I Prognostic TMA represents a collection of 590 stage I invasive breast cancer tissue specimens with associated clinico-pathologic data and clinical follow-up information. These cases are divided into five non-overlapping case sets. The case sets are labeled case sets 9-13 to distinguish them from case sets used on previous TMAs. Each case set is arrayed in quadruplicate, producing a total of 20 TMA blocks. Table 1 below gives the distribution of breast tissue and control samples across the 5 case sets. The number of cores represented on any single TMA section is 146 (126 breast tissue cores + 20 control cores). Normal breast epithelium cores will be 1.0 mm and all other cores will be 0.6 mm in diameter. An applicant whose request for the Stage I Prognostic TMA is approved would be required to accept TMAs from all five case sets, with a minimum of two sections (from different replicate blocks) from each case set. Thus, the minimum number of TMA sections that any investigator would receive is ten (5 case sets × 2 replicate TMA blocks per case set × 1 section per TMA block). Click Here for the Excel map of sections[XLS] or Text alternative for map of sections.
Type of Case | Case Set 9 |
Case Set 10 |
Case Set 11 |
Case Set 12 |
Case Set 13 |
Total |
---|---|---|---|---|---|---|
Stage I invasive breast carcinoma | 118 | 118 | 118 | 118 | 118 | 590 |
Normal breast epithelium | 5 | 5 | 5 | 5 | 5 | 25 |
Breast fibroadenoma | 3 | 3 | 3 | 3 | 3 | 15 |
Total distinct breast tissue specimens | 126 | 126 | 126 | 126 | 126 | 630 |
Cell line controls | ||||||
MCF-7 | 2 | 2 | 2 | 2 | 2 | 10 |
MCF-10A | 2 | 2 | 2 | 2 | 2 | 10 |
SK-BR-3 | 2 | 2 | 2 | 2 | 2 | 10 |
SK-OV-3 | 2 | 2 | 2 | 2 | 2 | 10 |
T-47D | 2 | 2 | 2 | 2 | 2 | 10 |
Normal non-breast tissue controls | ||||||
Salivary gland | 2 | 2 | 2 | 2 | 2 | 10 |
Endometrium | 2 | 2 | 2 | 2 | 2 | 10 |
Colon | 2 | 2 | 2 | 2 | 2 | 10 |
Tonsil | 2 | 2 | 2 | 2 | 2 | 10 |
Prostate | 2 | 2 | 2 | 2 | 2 | 10 |
Total control cores per replicate TMA block | 20 | 20 | 20 | 20 | 20 | 100 |
Grand total cores per replicate TMA block | 146 | 146 | 146 | 146 | 146 | 730 |
The CDP 2008 Series Stage II Prognostic TMA represents a collection of 398 stage II invasive breast cancer tissue specimens with associated clinico-pathologic data and clinical follow-up information. These cases are divided into four non-overlapping case sets. The case sets are labeled case sets 14-17 to distinguish them from case sets used on previous TMAs. Each case set is arrayed in quadruplicate, producing a total of 16 TMA blocks. Table 2 below gives the distribution of breast tissue and control samples across the 4 case sets. The number of cores represented on any single TMA section is 127-128 (107-108 breast tissue cores + 20 control cores). Normal breast epithelium cores will be 1.0 mm and all other cores will be 0.6 mm in diameter. An applicant whose request for the Stage II Prognostic TMA is approved would be required to accept TMAs from all four case sets, with a minimum of two sections (from different replicate blocks) from each case set. Thus, the minimum number of TMA sections that any investigator would receive is eight (4 case sets × 2 replicate TMA blocks per case set × 1 section per TMA block). Click Here for the Excel map of sections[XLS] or Text alternative for map of sections.
Type of Case | Case Set 14 |
Case Set 15 |
Case Set 16 |
Case Set 17 |
Total |
---|---|---|---|---|---|
Stage II invasive breast carcinoma | 99 | 99 | 100 | 100 | 398 |
Normal breast epithelium | 5 | 5 | 5 | 5 | 20 |
Breast fibroadenoma | 3 | 3 | 3 | 3 | 12 |
Total distinct breast tissue specimens | 107 | 107 | 108 | 108 | 430 |
Cell line controls | |||||
MCF-7 | 2 | 2 | 2 | 2 | 8 |
MCF-10A | 2 | 2 | 2 | 2 | 8 |
SK-BR-3 | 2 | 2 | 2 | 2 | 8 |
SK-OV-3 | 2 | 2 | 2 | 2 | 8 |
T-47D | 2 | 2 | 2 | 2 | 8 |
Normal non-breast tissue controls | |||||
Salivary gland | 2 | 2 | 2 | 2 | 8 |
Endometrium | 2 | 2 | 2 | 2 | 8 |
Colon | 2 | 2 | 2 | 2 | 8 |
Tonsil | 2 | 2 | 2 | 2 | 8 |
Prostate | 2 | 2 | 2 | 2 | 8 |
Total control cores per replicate TMA block | 20 | 20 | 20 | 20 | 80 |
Grand total cores per replicate TMA block | 127 | 127 | 128 | 128 | 510 |
The CDP 2008 Series Stage III Prognostic TMA represents a collection of 181 stage III invasive breast cancer tissue specimens with associated clinico-pathologic data and clinical follow-up information. These cases are divided into two non-overlapping case sets. The case sets are labeled case sets 18-19 to distinguish them from case sets used on previous TMAs. Each case set is arrayed in quadruplicate, producing a total of 8 TMA blocks. Table 3 below gives the distribution of breast tissue and control samples across the 2 case sets. The number of cores represented on any single TMA section is 118 or 119 (98 or 99 breast tissue cores + 20 control cores). Normal breast epithelium cores will be 1.0 mm and all other cores will be 0.6 mm in diameter. An applicant whose request for the Stage III Prognostic TMA is approved would be required to accept TMAs from both case sets, with a minimum of two sections (from different replicate blocks) from each case set. Thus, the minimum number of TMA sections that any investigator would receive is four (2 case sets × 2 replicate TMA blocks per case set × 1 section per TMA block). Click Here for the Excel map of sections[XLS] or Text alternative for map of sections.
Type of Case | Case Set 18 |
Case Set 19 |
Total | |||
---|---|---|---|---|---|---|
Stage III invasive breast carcinoma | 91 | 90 | 181 | |||
Normal breast epithelium | 5 | 5 | 10 | |||
Breast fibroadenoma | 3 | 3 | 6 | |||
Total distinct breast tissue specimens | 99 | 98 | 197 | |||
Cell line controls | ||||||
MCF-7 | 2 | 2 | 4 | |||
MCF-10A | 2 | 2 | 4 | |||
SK-BR-3 | 2 | 2 | 4 | |||
SK-OV-3 | 2 | 2 | 4 | |||
T-47D | 2 | 2 | 4 | |||
Normal non-breast tissue controls | ||||||
Salivary gland | 2 | 2 | 4 | |||
Endometrium | 2 | 2 | 4 | |||
Colon | 2 | 2 | 4 | |||
Tonsil | 2 | 2 | 4 | |||
Prostate | 2 | 2 | 4 | |||
Total control cores per replicate TMA block | 20 | 20 | 40 | |||
Grand total cores per replicate TMA block | 119 | 118 | 237 |
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