NIDA Research Monograph, Number 112 [Printed in 1991]
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Table of Contents
Foreword-----iii
Emerging Technologies and New Directions in Drug Abuse
Research: An Overview-----1
Rao S. Rapaka, Alexandros Makriyannis,
and Michael J. Kuhar
Voronoi Binding Site Models-----7
Gordon M. Crippen
A Mechanistic Basis for Design of Selective Agonists for 5-HT
Receptors-----21
Roman Osman and Harel Weinstein
Computer-Aided Drug Design for the Benzodiazepine
Receptor Site-----43
Gilda H. Loew, Hugo O. Villar, Waymond Jung,
and M. Frances Davies
3D-Searching: An Overview of a New Technique for
Computer-Assisted Molecular Design-----62
Robert S. Pearlman
Protein Structure Determination in Solution Using Nuclear Magnetic
Resonance Spectroscopy-----76
Angela M. Gronenborn and G. Marius Clore
Combined Use of Solid-State Nuclear Magnetic Resonance
Spectroscopy, Small-Angle X-Ray Diffraction, and Differential
Scanning Calorimetry in Studies of Cannabinoid: Membrane
Interactions-----106
Alexandros Makriyannis, De-Ping Yang,
and Thomas Mavromoustakos
Characterization and Localization of Cannabinoid Receptors in
Brain: An In Vitro Technique Using Slide-Mounted Tissue
Sections-----129
Miles Herkenham
New Developments in Radiotracers for Positron Emission
Tomography-----146
Joanna S. Fowler and Alfred P. Wolf
Use of Positron Emission Tomography To Study Cocaine in the
Human Brain-----166
Nora D. Volkow, Joanna S. Fowler,
and Alfred P. Wolf
Development of Opioid Peptide Analogs as Pharmacologic
Tools and as Potential Drugs: Current Status and Future
Directions-----180
Peter W. Schiller
Conformational Analysis of Opioid Receptor-Selective
Peptides Using Nuclear Magnetic Resonance and Theoretical
Calculations-----198
Victor J. Hruby, Om Prakash,
Wieslaw Kazmierski, Catherine Gehrig,
and Terry O. Matsunaga
Peptidomimetic Opioids-Synthesis, Spectroscopy, and Computer
Simulations-----218
Murray Goodman, Odile E. Said-Nejad,
Eduard Felder, Dale F. Mierke,
Toshimasa Yamazaki, and Peter W. Schiller
Modified Solid-Phase Methods for the Rapid Synthesis of
Opioid Peptides-----239
Richard A. Houghten, John M. Ostresh,
and Suzanne M. Pratt
Irreversible Ligands as Probes for Drug Receptors-----256
Amy Hauck Newman
Important Compounds in the Cocaine Class: A Synthesis
Overview-----284
F.I. Carroll and Anita H. Lewin
lmmunomodulatory Effects of Drugs of Abuse and the
Importance of Structure-lmmunomodulatory Activity Studies-----300
Rao S. Rapaka and Charles P. Hoiberg
FDA Regulatory Requirements for Investigational New Drugs
and New Drug Applications: An Update-----313
Charles P. Hoiberg and Rao S. Rapaka
List of NIDA Research Monographs-----326
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