NIDA Research Monograph, Number 114 [Printed in 1991]

Download Monograph114.pdf - Methodological Issues in Controlled Studies on Effects of Prenatal Exposure to Drug Abuse (1.5 MB)

Table of Contents

Preface-----vii
M. Madyne Kilbey and Khursheed Asghar

Session: Detection and Quantification of Prenatal Drug Exposure in Infants

Drug Exposure to the Fetus-The Effect of Smoking-----1
Betty R. Kuhnert

Pharmacokinetic Correlates of Fetal Drug Exposure-----18
C. Lindsay DeVane

Discussion: Methodological Issues in Controlled Studies on Effects of Prenatal Drugs-----37
Hazel H. Szeto

Session: Assessment of Pregnancy Outcome

Selected Methodologic Issues in Investigations of Prenatal Effects of Cocaine: Lessons From the Past-----45
Barry Zuckerman

Methodological Issues in Studying Cocaine Use in Pregnancy: A Problem of Definitions-----55
lra J. Chasnoff

Use of Birth Defects Monitoring Programs for Assessing the Effects of Maternal Substance Abuse on Pregnancy Outcomes-----66
M. Louise Martin and Larry D. Edmonds

Discussion: Methodologic Issues in Assessment of Pregnancy Outcomes-----84
Ronald A. Chez

Session: Assessment of Status of the Newborn

What We Can Learn From the Status of the Newborn-----93
T. Berry Brazelton

Neurobehavioral Organization of the Newborn: Opportunity for Assessment and Intervention-----106
Heidelise Als

Substance Abuse in Pregnancy: Effects on Cardiorespiratory Function in the Infant-----117
Eduardo Bancalari

The Effect of Cocaine on Developing HumanBrain-----128
Barry E. Kosofsky

Discussion: Assessing Status of the Newborn-----144
Edward Z. Tronick

Session: Measurement of Drug-Induced Physical and Behavioral Delays and/or Abnormalities: A General Framework

Measurement of Drug-Induced Physical and Behavioral Delays and Abnormalities in Animal Studies: A General Framework-----148
Sheldon B. Sparber

Regulatory Disorders I: Clinical Perspectives-----165
Stanley I. Greenspan

Regulatory Disorders II: Psychophysiologic Perspectives-----173
Stephen W. Porges and Stanley I. Greenspan

Discussion: Measurement of Drug-Induced Physical and Behavioral Delays and Abnormalities-A General Framework-----182
Joseph L. Jacobson

Session: Measurement of Drug-Induced Physical and Behavioral Delays and/or Abnormalities: (A) Physiology and (B) Neuroendocrinology

Postnatal Development of Cardiac and Respiratory Control Following Prenatal Drug Exposure-----187
Ronald M. Harper

Endocrine Function as a Target of Perinatal Drug Effects: Methodologic Issues-----206
Cynthia Kuhn, Diane Ignar, and Rolf Windh

Discussion: Neuroteratology of Cocaine Relationship to Developing Monoamine Systems-----233
Jean M. Lauder

Session: Measurement of Drug-Induced Physical and Behavioral Delays and/or Abnormalities: (C) Learning and Cognition and (D) Social Bonding/Emotional and Development

Assessment of Teratogenic Effects on Cognitive and Behavioral Development in Infancy and Childhood-----248
Joseph L. Jacobson and Sandra W. Jacobson

New Methodologies for Evaluating Residual Brain Damage In Infants Exposed to Drugs of Abuse: Objective Methods for Describing Movements, Facial Expressions, and Communicative Behaviors-----262
Edward Z. Tronick, Marjorie Beeghly, Linda Fetters, and M. Katherine Weinberg

Rationale and Methodologies for Developing Nonhuman Primate Models of Prenatal Drug Exposure-----291
Stephen J. Suomi and J. Dee Higley

Discussion: Measurement of Drug-Induced Delays in Learning and Cognition and Social and Emotional Development-----303
Sheldon B. Sparber

Session: Tracking Drug Effects Over the Lifespan

Following Drug-Exposed Infants Into Middle Childhood: Challenges to Researchers-----310
Sydney L. Hans

Patterns of Growth and Development in Narcotic-Exposed Children-----323
Marta H. Lifschitz and Geraldine S. Wilson

Integrity of Psychopathology Diagnoses Across the Lifespan-----340
Patricia Cohen and Judith S. Brook

Discussion: Drug Effects-A Search for Mechanisms-----352
Barry Zuckerman

List of NIDA Research Monographs-----363