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Assessing Neurotoxicity of Drugs of Abuse



NIDA Research Monograph, Number 136 [Printed in 1993]

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Table of Contents

Preface-----v
Lynda Erinoff

Neurobehavioral Methods Used in Neurotoxicology-----1
Hugh A. Tilson

Behavioral Consequences of Partial Monoamine Depletion in the CNS After Methamphetamine-Like Drugs: The Conflict Between Pharmacology and Toxicology-----34
Lewis S. Seiden, William L. Woolverton, Stanley A. Lorens, Joseph E.G. Williams, Rebecca L. Corwin, Norio Hata, Mary Olimski

Strategies for Detecting Subclinical Monoamine Depletions in Humans-----53
Una D. McCann and George A. Ricaurte

Sensory Evoked Potentials: Measures of Neurotoxicity-----63
William K. Boyes

Silver Staining as a Tool for Neurotoxic Assessment-----101
Carlos A. Beltramino, José de Olmos, Ferenc Gallyas, Lennart Heimer, and Lászó Záborszky

Mapping Toxicant-Induced Nervous System Damage With a Cupric Silver Stain: A Quantitative Analysis of Neural Degeneration Induced by 3,4-Methylenedioxymethamphetamine-----133
Karl F. Jensen, Jeanene Olin, Najwa Haykal-Coates, James O'Callaghan, Diane B. Miller, and José S. de Olmos

Reactions of 5-HT Neurons to Drugs of Abuse: Neurotoxicity and Plasticity-----155
Mary Ann Wilson, Laura A. Mamounas, Kenneth H. Fasman, Karen J. Axt, and Mark E. Molliver

Quantification of Reactive Gliosis as an Approach to Neurotoxicity Assessment-----188
James P. O'Callaghan and Diane B. Miller

Pharmacokinetic Approaches to the Study of Drug Action and Toxicity-----213
Arthur K. Cho, Masayuki Hiramatsu, Yoshito Kumagai, and Nita Patel

Mechanisms Mediating Biogenic Amine Deficits Induced by Amphetamine and Its Congeners-----226
James W. Gibb, Michel Johnson, Donna M. Stone, and Glen R. Hanson

Neurotoxicity and Drugs of Abuse: Cannabinoid Interaction With Brain Glucocorticoid Receptors-----242
Philip W. Landfield and J. Charles Eldridge

Nitric Oxide as a Mediator of Neurotoxicity-----253
Ted M. Dawson, Valina L. Dawson, and Solomon H. Snyder

List of NIDA Research Monographs-----274




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