Protocol Details

Clinical and Molecular Studies in Families with Myopia and Related Diseases

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	06-EI-0058
Sponsoring Institute	National Eye Institute (NEI)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 4 Max Age: N/A
Referral Letter Required	Yes
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Nearsightedness; Molecular Genetics; Positional Cloning; Refraction; Linkage; Myopia; High Myopia
Recruitment Keyword(s)	Myopia; Nearsightedness
Condition(s)	Myopia
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Eye Institute

This study will examine the inheritance of myopia in families of various nationalities and ethnic backgrounds to identify gene changes that cause myopia or similar diseases and to better understand these conditions. In patients with myopia, the eye does not focus light accurately on the retina (tissue that lines the back of the eye), so that objects at a distance appear blurry. Myopia may occur alone, with other vision problems such as retinal dislocations, cataract or glaucoma, or with other problems such as joint or skin problems.

People with myopia (usually those from families with several affected members) and control subjects with normal vision may be eligible for this study.

Each participant undergoes the following procedures:

-Blood draw for genetic testing related to the disorders under study

-Medical and family history, including drawing a family tree to explore vision problems in the family

-Complete eye examination, including refraction (pupil dilation) and visual acuity testing, photographs of the retina and possibly lens, and specialized tests to measure field of vision, color vision and ability to see in the dark

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Eligibility

INCLUSION CRITERIA:

1. Individuals or family members of individuals with myopia, either congenital, childhood, or older.

2. Adults must be capable of providing their own consent.

3. All subjects must be able to cooperate with study examination and phlebotomy.

4. Older than 4 years of age.

EXCLUSION CRITERIA:

1. Diseases, infections, or trauma that mimic primary myopia.

2. Children requiring sedation for study procedures.

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Citations:

Mutti DO, Mitchell GL, Moeschberger ML, Jones LA, Zadnik K. Parental myopia, near work, school achievement, and children's refractive error. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3633-40.

Teikari JM, O'Donnell J, Kaprio J, Koskenvuo M. Impact of heredity in myopia. Hum Hered. 1991;41(3):151-6.

Zhang Q, Guo X, Xiao X, Yi J, Jia X, Hejtmancik JF. Clinical description and genome wide linkage study of Y-sutural cataract and myopia in a Chinese family. Mol Vis. 2004 Nov 17;10:890-900.

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Contacts:

Principal Investigator	Referral Contact	For more information:
James F. Hejtmancik, M.D. National Eye Institute (NEI) National Institutes of Health Building 10 Room 10B10 10 Center Drive MSC 1860 Bethesda, Maryland 20892-1860 (301) 435-1598 jh1b@nih.gov	James F. Hejtmancik, M.D. National Eye Institute (NEI) National Institutes of Health Building 10 Room 10B10 10 Center Drive MSC 1860 Bethesda, Maryland 20892-1860 (301) 435-1598 jh1b@nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00272376

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