Protocol Details

Screening Study for the Evaluation and Diagnosis of Potential Research Participants

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	08-EI-0102
Sponsoring Institute	National Eye Institute (NEI)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: N/A Max Age: N/A
Referral Letter Required	No
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Screening Protocol
Recruitment Keyword(s)	Eye Diseases
Condition(s)	Eye Diseases
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Eye Institute

This study will allow National Eye Institute (NEI) doctors the opportunity to examine people with eye disease, whether the diagnosis is known or not, to determine if they are eligible for other NEI research studies. No treatment is offered in this study.

People of all ages with various eye conditions, including genetic conditions, eye movement disorders, inflammatory eye diseases, retinal diseases and external eye diseases, may be eligible for this study.

Participants undergo various tests and procedures to diagnose or evaluate their eye disease. The procedures may include the following:

-Personal and family medical history

-Physical examination and blood tests, including genetic testing.

-Eye examination with dilation to measure visual acuity and eye pressure and to examine the front and back parts of the eye.

-Questionnaire about vision and daily activities.

-Conjunctival swab or lacrimal bland biopsy, or both: A sample of cells from the eyes is collected by swabbing the surface of the eye or by surgically removing a small sample of the surface of the eye or tear gland.

-Electroretinogram to examine retinal function: The subject sits in the dark with his or her eyes patched for 30 minutes. The patches are removed, the surface of the eyes is numbed, and contact lenses that can sense signals from the retina are placed on the eyes. The subject then watches flashing lights.

-Fluorescein angiography to examine the blood vessels in the eye: A dye is injected into a vein in the arm. The dye travels through the veins to the blood vessels in the eyes. A camera takes pictures of the dye as it flows through the blood vessels.

-Optical coherence tomography to measure retinal thickness: A machine used to examine the eyes produces cross-sectional pictures of the retina.

-Microperimetry to test how sensitive different parts of the retina are to changing levels of light. The subject sits in front of a computer and presses a button when he or she sees a light on the screen.

-Oculography to record eye movements: Eye movements are measured by contact lenses or goggles that the subject wears while watching a series of spots on a computer screen.

--Back to Top--

Eligibility

INCLUSION CRITERIA:

Participants will be able to enroll if they:

1. Have a diagnosed ocular disease; OR

2. Have an unusual, interesting, or unknown ocular condition that requires the establishment of a diagnosis; AND

3. Have the ability to understand and sign an informed consent OR if they are minor children, have a legal parent/guardian with the ability to do the same.

EXCLUSION CRITERIA:

Participants will be unable to enroll if they:

1. Have no medical conditions; OR

2. Are unwilling or unable to cooperate with the study procedures.

--Back to Top--

Citations:

Not Provided

--Back to Top--

Contacts:

Principal Investigator	Referral Contact	For more information:
Awilda V. Holland National Eye Institute (NEI) National Institutes of Health Building 10 Room 10D45 10 Center Drive Bethesda, Maryland 20892 (301) 435-7831 aholland@nei.nih.gov	Wendy Holland, R.N. National Eye Institute (NEI) National Institutes of Health Building 10 Room 10D45 10 Center Drive Bethesda, Maryland 20892 (301) 435-1831 aholland@nei.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00655096

--Back to Top--

QUESTIONS?

Contact the Patient Recruitment and Public Liaison Office for:

• Details on how to participate in a study
• Details on how to refer a patient to a study

NIH Clinical Studies Information Request

---

Contact the Office of Communications for:

• General information about the NIH Clinical Center

www.cc.nih.gov/contact.shtml

---

Contact the Department Clinical Research Informatics, (DCRI) for:

• Technical questions about Adobe Acrobat and the PDF format
• Technical questions about this web server

webmaster@cc.nih.gov