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AMD Phenotype and Genotype Study (APGS)
This study is currently recruiting participants.
Summary | Eligibility | Citations | Contacts
Summary
Number |
13-EI-0027 |
Sponsoring Institute |
National Eye Institute (NEI) |
Recruitment Detail |
Type: Participants currently recruited/enrolled |
Referral Letter Required |
No |
Population Exclusion(s) |
Children |
Special Instructions |
Currently Not Provided |
Keywords |
Phenotype-Genotype correlation; |
Recruitment Keyword(s) |
None |
Condition(s) |
Age-Related Macular Degeneration; |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
|
- Age-related macular degeneration (AMD) is a disease that blurs the sharp vision needed for activities such as reading, sewing, and driving. It affects the macula, the center of the retina at the back of the eye, which allows a person to see fine detail. Researchers want to collect medical histories, eye exam data, and genetic information that may be associated with AMD. They want to compare this information with information collected from people without AMD.
Objectives:
- To collect medical information and gene samples for researchers studying AMD.
Eligibility:
- Individuals between and 60 and 90 years of age who have AMD in at least one eye.
- Individuals between and 60 and 90 years of age who have no AMD in either eye.
Design:
- This study will involve one study visit. This study visit will last 6 to 8 hours.
- Participants will have the following tests and exams as part of their study visit:
- Full physical exam and medical history
- Full eye examination
- Laser scan of the eye
- Retina function test
- Vision sensitivity test
- Optional blood sample (for genetic study)
- No treatment will be provided as part of this study.
Eligibility
INCLUSION CRITERIA:1. Male or female participants with AMD in at least one eye (case) or no AMD in either eye (control).
2. Ages 60 to 90
3. Ability to provide written informed consent and comply with study assessments for the full duration of the study
4. Retinal photographs of sufficient quality to allow assessment of the macular area for AMD lesions including drusen
EXCLUSION CRITERIA:
1. Presence of lens or vitreous opacity in eye(s) with AMD to preclude adequate ophthalmic imaging
2. Presence of ocular conditions that may now or in the future complicate the evaluation of AMD; e.g., vascular occlusion, diabetic retinopathy (less than 4 microaneurysms), etc., in the eye(s) with AMD.
3. High myopia -6 Diopters or more severe
4. Diagnosis of nystagmus
Citations:
Contacts:
Principal Investigator |
Referral Contact |
For more information: |
| Wai T. Wong, M.D. National Eye Institute (NEI) National Institutes of Health Building 7 Room 238 7 Center Drive Bethesda, Maryland 20892 (301) 496-7821 wongw@mail.nih.gov |
Katherine H. Shimel, R.N. National Eye Institute (NEI) National Institutes of Health Building 10 Room 10S215 10 Center Drive Bethesda, Maryland 20892 (301) 402-2863 shimelk@nei.nih.gov |
Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov |
Clinical Trials Number:
NCT01778491
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