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Research in NIAMS Labs

Updated January 28, 2013

Photo of Dr. John O'Shea, NIAMS Scientific Director

Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director

As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.

RPA Accumulation during Class Switch Recombination

Casellas Group Develops a New DNA Damage Visualization Technique and Sheds Light on DNA Damage & Class Switching in Two Papers

The technique consists of detecting by immunoprecipitation and deep-sequencing recruitment of RPA to DNA breaks under conditions where homologous recombination is favored.
Cell Rep. 2013 Jan 1. doi:pii: S2211-1247(12)00431-7. 10.1016
Science. 2013 Jan 10.

Different dimer structures of HBV e-antigen

Dr. Steven Group Solves the Crystal Structure of Hepatitis B Virus e-antigen

The structure sheds light on a three-decades mystery and offers insight into how HBV e-antigen may establish immune tolerance for HBV core-antigen while evading its robust immunogenicity.
Structure . 2012 Dec 5. pii: S0969-2126(12)00414-5. doi: 10.1016/j.str.2012.10.017.

Different lymphoid cells subsets in the gut

Dr. O'Shea's Lab Shows Distinct Requirements for T-bet in Gut Innate Lymphoid Cells.

The study shows that the transcription facotr T-bet is important for innate lymphoid cells in the gut and plays a selective and critical role in the generation of a specific natural killer cells subset
J Exp Med . 2012 Dec 3.

T helper subsets have thousands of unique p300 binding sites, but almost none are shared among T cells, macrophages, and ES cells. Venn diagram depicts the number and percentages of shared and unique p300 binding sites in each cell type.

Drs. O'Shea and Sartorelli Show a Critical Role of STATs as Environmental Sensors Shaping T Cell Populations

Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. The paper shows that STATs aare criticial for molding the specialized enhancer architecture of differentiating cells.
Cell. 2012 Nov 21;151(5):981-93. doi: 10.1016/j.cell.2012.09.044.