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NHLBI Umbilical Cord Blood Unit Collection

Study Type: Epidemiology Study
Prepared on August 24, 2009
Study Dates: 1998-2001
Consent: Restricted Consent
Consent Restrictions: Restrictions prohibit use for cell line production.
Commercial Use Restrictions: Yes
NHLBI Division: DBDR
Collection Type: Open BioLINCC Study - See bottom of this webpage for request information


The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.


Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.


The CBU were collected under standard operating procedures described in detail elsewhere (1) (


The CBU were collected under standard operating procedures described in detail elsewhere (1) (


J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).
M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).
J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).