Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)
This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00000579
First received: October 27, 1999
Last updated: August 24, 2006
Last verified: August 2006
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Purpose
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The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical Care Treatment Groups (CCTGs) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs, approved agents not currently used for treatment of ARDS, or treatments currently used but whose efficacy has not been well documented.
Condition | Intervention | Phase |
---|---|---|
Respiratory Distress Syndrome, Adult Lung Diseases |
Procedure: Low Tidal Volume Ventilation Procedure: Positive End-Expiratory Pressure Drug: Lysofylline Drug: Methylprednisolone Drug: Ketoconazole Procedure: Fluid Management Procedure: Pulmonary Artery Catheter |
Phase 3 |
Study Type: | Interventional |
Study Design: | Intervention Model: Factorial Assignment Primary Purpose: Treatment |
Official Title: | Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) |
Resource links provided by NLM:
Drug Information available for:
Prednisolone
Prednisolone acetate
Methylprednisolone acetate
Methylprednisolone
Prednisolone Sodium Phosphate
Prednisolone phosphate
Methylprednisolone Sodium Succinate
Ketoconazole
U.S. FDA Resources
Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):
Primary Outcome Measures:
- Vary by protocol
Study Start Date: | September 1994 |
Eligibility
Ages Eligible for Study: | 13 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Men and women
- 13 years of age or older
- ARDS or risk factors for ARDS (patients will be considered at risk if they are critically ill and have trauma, sepsis, shock, pneumonia, inhalation injury, drug overdose, pancreatitis, or hypertransfusion)
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000579
Show 21 Study Locations
Show 21 Study Locations
Sponsors and Collaborators
Investigators
Principal Investigator: | Edward Abraham, MD | University of Colorado, Denver |
Principal Investigator: | Antonio Anzueto, MD | University of Texas |
Principal Investigator: | Roy Brower, MD | Johns Hopkins University |
Principal Investigator: | Alfred F. Connors, MD | University of Virginia |
Principal Investigator: | Bennett P. deBoisblanc, MD | Louisiana State University Health Sciences Center in New Orleans |
Principal Investigator: | Bennett P. deBoisblanc, MD | Louisiana State University Health Science Center |
Principal Investigator: | Michael Donahoe, MD | University of Pittsburgh |
Principal Investigator: | Kalpalatha K. Guntupalli, MD | Baylor College of Medicine |
Principal Investigator: | Robert D. Hite, MD | Wake Forest University |
Principal Investigator: | Rolf Hubmayr, MD | Mayo Clinic |
Principal Investigator: | Neil MacIntyre, MD | Duke University |
Principal Investigator: | Michael A. Matthay, MD | University of California, San Francisco |
Principal Investigator: | Alan Morris, MD | Latter Day Saints Hospital |
Principal Investigator: | Michael J. Murray | Mayo Foundation |
Principal Investigator: | James A. Russell, MD | University of British Columbia |
Principal Investigator: | Gregory A. Schmidt, MD, FCCP | University of Chicago |
Principal Investigator: | David A. Schoenfeld, PhD | Massachusetts General Hospital |
Principal Investigator: | Jay S. Steingrub, MD, FCCP | Baystate Medical Center |
Principal Investigator: | Arthur Wheeler, MD | Vanderbilt University |
Principal Investigator: | Herbert Wiedemann, MD | Cleveland Clinic Lerner College of Medicine |
More Information
Additional Information:
Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on February 14, 2013
Additional Information:
Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: | NCT00000579 History of Changes |
Other Study ID Numbers: | 217, N01 HR16146, N01 HR16147, N01 HR16148, N01 HR16149, N01 HR16150, N01 HR16151, N01 HR16152, N01 HR16153, N01 HR16154, N01 HR16155, N01 HR46054, N01 HR46055, N01 HR46056, N01 HR46057, N01 HR46058, N01 HR46059, N01 HR46060, N01 HR46061, N01 HR46062, N01 HR46063, N01 HR46064, N01 HR56165, N01 HR56166, N01 HR56167, N01 HR56168, N01 HR56169, N01 HR56170, N01 HR56171, N01 HR56172, N01 HR56173, N01 HR56174, N01 HR56175, N01 HR56176, N01 HR56179 |
Study First Received: | October 27, 1999 |
Last Updated: | August 24, 2006 |
Health Authority: | United States: Federal Government |
Additional relevant MeSH terms:
Lung Diseases Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Respiratory Tract Diseases Respiration Disorders Infant, Premature, Diseases Infant, Newborn, Diseases Lung Injury Ketoconazole Methylprednisolone acetate Prednisolone acetate Methylprednisolone Methylprednisolone Hemisuccinate Prednisolone |
Prednisolone hemisuccinate Prednisolone phosphate 14-alpha Demethylase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Antifungal Agents Anti-Infective Agents Therapeutic Uses Anti-Inflammatory Agents Antiemetics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Central Nervous System Agents |
ClinicalTrials.gov processed this record on February 14, 2013