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Cancer - Research Materials:

DateRef. No.Patent No.Title
1/11/2013E-264-2011/0 Virus-Like Particles Mediated Protein and RNA Delivery
11/16/2012E-230-2012/0 A New Class, Now in Session: the First HLA Class II Restricted T Cell Receptor that Recognizes the Cancer Testis Antigen, MAGE-A3, Developed for Cancer Immunotherapy
11/15/2012E-267-2012/0 A Novel Immortalized Human Adrenal Cell Line with Inactive Protein Kinase A for Studies on cAMP Signaling and Endocrine Tumorigenesis
9/10/2012E-136-2012/0 High-Affinity Mouse Monoclonal Antibodies to Glypican-3 (GPC3) for Treatment of Cancer
8/28/2012E-277-2001/0 Immunoglobulin-producing Mouse Plasmacytomas
8/17/2012E-274-2008/0 Monoclonal Antibodies to the Tumor-Specific Antigen, Human ROR1
8/1/2012E-071-2007/0 Transgenic Mouse Model Useful for the Study of Myelodysplastic Syndrome
7/31/2012E-261-2007/0 Mouse Embryonic Stem Cell-based Functional Assay to Evaluate Mutations in BRCA2
7/31/2012E-216-2009/0 High Diversity/High Affinity Domain Antibody Library
5/24/2012E-177-2012/0 Rabbit Polyclonal Antibody to Detect a Pro-peptide Fragment of NSAID-activated Gene (NAG-1)/GDF15, a Protein Associated with Cancer
5/1/2012E-021-2011/0 Potential Chemotherapeutic Agents: Synthetic Peptide Inhibitors of the Wnt Pathway
4/30/2012E-097-2012/0 Mouse Monoclonal Antibody Targeting Human NOX1, a Target for Cancer and Inflammation
4/30/2012E-233-2011/0 Cell Line for Producing Furin That Can Cleave Papillomavirus L2, Toxins and Other Substrates
4/19/2012E-036-2008/0 Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme
4/19/2012E-111-2012/0 Stat1LoxP (Stat1tm1Mam) Mouse Model for Oncology and Immunology Studies
4/19/2012E-113-2012/0 Tg(MMTV-Cre)#Mam Mouse Model for Developmental Biology, Hepatology, and Oncology Studies
4/19/2012E-118-2012/0 UTX LoxP Mouse Model for Oncology Research
4/19/2012E-120-2012/0 Sirt1 Knockout (Sirt1tm1.1Cxd) Mouse Model for Oncology and Metabolism Studies
3/29/2012E-011-1998/0 6,849,417
7,442,543
7,776,607
Mammalian Selenoprotein Differentially Expressed in Tumor Cells
3/23/2012E-267-2010/0 T Lymphocyte (T cell) Clones that Recognize the Tumor Associated Antigens gp100 and MART-1
3/20/2012E-215-2011/0 The Cancer Stem Cell Finder: A Novel Reporter Construct which uses Transposition and Green Fluorescent Protein Expression to identify Cancer Stem Cells
2/29/2012E-149-2011/0 NOX5 Immunogenic Peptides and Monoclonal Antibodies for the Detection of Cancer and Inflammatory Responses
2/22/2012E-033-2012/0 Model Cell Lines With and Without AKT1 Mutations Derived from Proteus Syndrome Patients
1/18/2012E-231-2010/0 Transgenic Human Interleukin-21 Mouse Model
1/17/2012E-212-2011/0 Monospecific and Bispecific Human Monoclonal Antibodies Targeting IGF-II
10/28/2011E-266-2011/0 New non-HLA-A2 Restricted Human T Cell Receptors (TCRs) that Could be Used to Treat a Broader Cancer Patient Population Via TCR Adoptive Immunity
9/30/2011E-094-1994/0 7,070,972
7,488,808
7,902,348
Janus Family Kinases (JAK) And Identification Of Immune Modulators
9/29/2011E-123-2010/0 mGluR5 Tumor Mouse Model
9/26/2011E-302-2009/0 Mouse Xenograft Model for Mesothelioma
9/23/2011E-068-2011/0 Human Monoclonal Antibodies Cross-reacting to Insulin-like Growth Factors IGF-I and IGF-II as Potential Anti-tumor Agents
8/9/2011E-173-2010/0 Immunocompetent Mouse Model for Tracking Cancer Progression
7/1/2011E-175-2011/0 Mouse Model and Derived Cells That Hypersecrete Leukemia Inhibitory Factor (LIF)
6/24/2011E-296-2010/0 Efficient Production of Functional Recombinant Human Neonatal Receptor (FcRn) Proteins
6/14/2011E-229-2010/0 ERBB4 Mutations Identified in Human Melanoma Metastasis Cell Lines (2690, 2379, 2197, 2183, 2535, 2645, 1770, 2359, 2238, 2319, 2190)
4/19/2011E-254-2010/0 UOK 268 Cell Line for Hereditary Leiomyomatosis and Renal Cell Carcinoma
4/14/2011E-093-2011/0 NAG-1 Transgenic Mouse Model
4/12/2011E-281-2007/0
E-281-2007/1
Three-Dimensional Co-Culture Assay System for Angiogenesis and Metastasis
4/4/2011E-234-2010/1 Diagnostic and Prognostic Serum Biomarkers for Cancer Patients Treated with Cancer Vaccines
3/23/2011E-158-2010/0 Agonistic Human Monoclonal Antibodies Against DR4
2/28/2011E-236-2010/0 Versatile Melanoma Antigen Family A3 (MAGE-A3) Specific Human T Cell Receptors to Treat Cancer that also Recognize Other MAGE-A Antigen Superfamily Members
1/24/2011E-131-2010/0 The First Birt-Hogg-Dubé Tumor Cell Line and Wild Type Folliculin-restored Renal Cell Line as In Vitro and In Vivo Models
1/20/2011E-091-2008/0 Method for Detection and Quantification of PLK1 Expression and Activity
1/5/2011E-128-2009/0 GATA-3 Reporter Plasmids for Revealing Underlying Mechanisms in Breast Cancer
11/26/2010E-272-2010/0 Mouse Monoclonal Antibody for CEACAM
11/26/2010E-232-2010/0 Isocitrate Dehydrogenase 1 (IDH1) R132 Mutation Human Melanoma Metastasis Cell Line
11/9/2010E-100-2008/0 Cell Line PE, Developed From Mouse Skin Tumors, Demonstrates Unique Qualities
10/21/2010E-208-2009/0 Mouse Model of Thyroid Cancer
10/12/2010E-067-2010/0 Inverse Agonists of the TSH Receptor for the Treatment of Thyroid Cancer and Hyperthyroidism
10/12/2010E-198-2009/0 Mouse Anti-Mouse CXCL9 (Mig) Monoclonal Antibodies
10/8/2010E-220-2008/0
E-220-2008/1
E-220-2008/2
E-221-2008/0
E-221-2008/1
E-221-2008/2
E-222-2008/0
E-242-2008/0
E-243-2008/0
E-244-2008/0
E-245-2008/0
E-245-2008/1
E-252-2008/0
Antibodies and Antisera Recognizing Members of the ArfGap Family of Protein
9/20/2010E-119-2009/0 A New “Destination” for Protein Expression: A Lentiviral Gateway® Destination Vector for High-Level Protein Expression (pDEST-673)
9/9/2010E-198-2010/0 Assay for Arf GTP-binding Proteins
9/9/2010E-221-2009/0 Chemical Attraction: Cell Lines Expressing the CXCR1 or CXCR2 Chemokine Receptors
8/31/2010E-155-2010/0 An XMRV Tool Box: Expression Plasmids, Genes, and Proteins for All Components of the Xenotropic Murine Leukemia Virus-Related Virus (XMRV)
8/23/2010E-055-2009/0 Method of Producing Immortalized Primary Human Keratinocytes for HPV Investigation, Testing of Therapeutics, and Skin Graft Generation
8/17/2010E-016-2010/0 Transforming Growth Factor Beta-1 (TGF-beta1) Transgenic Mouse Model
8/3/2010E-106-2010/0 Software for Accurate Segmentation of Cell Nuclei in Breast Tissue
8/3/2010E-287-1987/0 Immortalized Human Bronchial Epithelial Cell Line
7/12/2010E-033-2010/0 UOK171, A Spontaneous Clear Cell Type Renal Cell Carcinoma (ccRCC) Human Cell Line Derived from a Surgically Removed Tumor
7/12/2010E-191-2010/0 A Transgenic Model of Human Basal Triple Negative Breast Cancer [C3(l)-tag mice]
7/7/2010E-070-2010/0 888-mel: A Target for Anti-Tumor Immune Responses
6/16/2010E-241-2005/0 Transgenic Mice in which the Gene for MCP-1 is Deleted
6/16/2010E-095-2000/2 Amelioration of Inflammatory Arthritis Targeting the Pre-ligand Assembly Domain (PLAD) of Tumor Necrosis Factor Receptors
6/16/2010E-264-2001/0 H002056A Mouse Model of von Hippel-Lindau Disease
6/14/2010E-135-2004/0 Retinal Pigment Epithelial Cells Immortalized with TERT and Expressing the Adenoviral E1A Oncoprotein
6/14/2010E-191-2002/0 7,205,334
7,521,475
8,278,348
Chondropsin-Class Antitumor V-ATPase Inhibitor Compounds, Compositions and Methods of Use Thereof
6/10/2010E-040-1993/0 5,833,986
5,863,739
Neutralizing Monoclonal Antibody To Human Alpha PDGF Receptors
6/10/2010E-014-2007/0 8,198,402Peptide and Peptidomimetic Inhibitors of Smoothened Protein as Anti-neoplastic Agents
6/7/2010E-009-2010/0 BODIPY®-FL Nilotinib (Tasigna®) for Use in Cancer Research
6/7/2010E-089-2010/0 Spontaneously Transformed Mouse Epithelial Cancer Cell Lines Serving as Mouse Models: A New Model for Cancer Research
6/7/2010E-331-2008/0
E-331-2008/1
Fully-human Monoclonal Antibodies Against Human EphrinB2 and EphB4 for Use in the Study of Cancer Pathogenesis
6/3/2010E-216-1994/0 6,057,346Inhibition of Retroviral LTR Promoters by Calcium Response Modifiers
4/12/2010E-059-2010/0 Tumor Tissues Harboring Mutations in cAMP-specific Phosphodiesterases Useful for the Study of Endocrine Tumors
3/15/2010E-048-2003/0 A Mouse Model for Conditional Gene Deletion of c-Met Receptor
3/11/2010E-245-2002/0 7,378,403Prevention and Treatment of Cancer with Kinase Inhibitors Targeting the PH Domain of AKT
3/1/2010E-058-2010/0 Patient-derived Gastrointestinal Stromal and Paraganglioma Tumor Samples Harboring Novel Stem Cell Factor FOXD3 Variants
1/22/2010E-295-2001/0 Imaging of Extracellular Proteases in Cells Using Mutant Anthrax Toxin Protective Antigens
12/2/2009E-005-2010/0 Human Renal Cell Carcinoma (RCC) Cell Lines Derived from Surgically Removed Tumors
12/1/2009E-146-2007/1 Selenocysteine Mediated Hybrid Antibody Molecules
10/12/2009E-345-2008/0 CXCR4 and CCR10 Expressing Cells: Useful for the Study of Cancer Cell Survival and Metastasis
8/11/2009E-058-2009/0 Development of a New Carbohydrate Antibody to GalNac1-3Gal
7/29/2009E-229-2009/0 A Tumorigenic MEF/3T3 Tet-Off Mouse Fibroblast Cell Line Stably Transfected with a T7-Tagged Srp20 Expression Construct (pJR17)
6/11/2009E-164-2007/0 Compounds Binding to the N-Terminal Domains of STAT Proteins as Therapeutic Agents
6/8/2009E-171-2009/0 Improved Antibodies Against ErbB4/Her4
5/28/2009E-101-2006/0 Tools to Identify Candidates for Effective Cancer Therapy: Antibodies to Human Asparagine Synthetase
5/28/2009E-162-2004/0 Mouse Model with Targeted Disruption of the Neurofibromatosis Type-1 (Nf1) Gene
5/15/2009E-129-2009/0 A549 Cells: A Well-Characterized Lung Carcinoma Cell Line Utilized for a Variety of Scientific Studies, including Adenovirus Production and Testing
5/4/2009E-154-2004/0 Creation and Characterization of Carcinogen-Altered Mouse Epidermal Cell Lines
5/4/2009E-159-2005/0 DU145 Camptothecin (CPT)-Resistant Cell Line
5/4/2009E-053-2006/0 Polyclonal Antibody Against Bloom's Syndrome Protein (BLM) for Research and Diagnostic Use
5/4/2009E-193-1997/0 6,555,367Targeted Recombinant Adenoviral Vectors
2/25/2009E-245-2003/0 Glutathione S-transferase Clones for Members of the Ubiquitin-Dependent Protein Degradation Pathway
12/1/2008E-003-2008/0 A Novel, Non-Invasive and Therapeutically Useful High Throughput Technique to Isolate Highly Enriched Tumor Reactive Lymphocytes from Peripheral Blood - Potential Use in Adoptive Immunotherapy
11/1/2008E-174-2008/0 Therapeutic Targeting of CSN5, a Negative Regulator of p53 and p27, in Human Hepatocellular Carcinoma
5/1/2008E-080-2008/0 Human and Improved Murine Monoclonal Antibodies Against CD22
5/1/2008E-079-2008/0 8357783Human Monoclonal Antibody Against Mesothelin
5/1/2008E-316-2007/0 Method of Inhibiting ABCG2 and Related Treatments
2/1/2008E-186-2007/2 Papilloma Pseudovirus for Detection and Therapy of Tumors
9/1/2007E-272-1998/0 6,790,948
7,431,926
7,919,590
8,206,937
Tumor Suppressor Genes
9/1/2007E-153-1998/0 7,256,256Peptide Inhibitor of Cyclin Dependent Kinase 4 (CDK4) Derived from MyoD
8/1/2007E-068-1998/0 6,685,933
7,235,232
Interferon Alpha Hybrids
5/1/2007E-281-2002/0 7,193,053Leu574 of HIF-1alpha as a Molecular Basis for Therapeutic Application
5/1/2007E-307-2004/1 Aminoalkyl Substituted O6-Benzylguanine Derivatives as Inactivators of O6-Alkylguanine-DNA Alkyltransferase and Adjuvants for Chemotherapy
1/1/2007E-293-2006/0 Megakaryocyte Potentiation Factor as a New Serum Tumor Marker for Mesothelioma
12/1/2006E-330-2003/0 Antisera to Detect Phosphorylated Phosphoinositide-Dependent Kinase 1 (PDK-1)
6/1/2006E-336-2005/0 8,071,323Novel Human IGF-1 Specific IGF-I and IGF-II Cross-Reactive Human Monoclonal Antibodies as Potential Anti-tumor Agents
3/1/2006E-262-1999/1 7,459,536Monoclonal Antibodies Which Specifically Bind to the Ligand Hepatocyte Growth Factor (HGF) and are Useful in the Treatment of Cancer
12/1/2005E-323-2003/0 7,589,181
7,915,396
Minimally Immunogenic Variants of SDR-Grafted Humanized Antibody CC49 and Their Use
12/1/2005E-264-2005/0 Mouse Polyclonal Antibodies to KAI1
10/1/2005E-327-2005/0 NIH3T3 Cell Lines Carrying c-Met Mutations Including G3906A, G3522A, G3810T, T3936C, T3936G, T3997C, C3528T, C3564G, C3831G, A3529T, and T3640C
10/1/2005E-274-2005/0 Murine Mast Cell Line Useful for Toxicity and Immunopotency Screens
10/1/2005E-167-1997/0 7,153,866The Use of Nitroxides in the Prophylactic and Therapeutic Treatment of Cancer Due to Genetic Defects
9/1/2005E-327-2004/0 A New Approach Toward Macrocyclization of Peptides
9/1/2005E-144-2005/0 Soluble Fragments of the IGF1R Ectodomain
9/1/2005E-087-1996/0 Heterologous Boosting Immunizations
8/1/2005E-168-2005/0 Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)
6/1/2005E-339-2004/0 7,855,276Framework Residue Substituted Humanized COL-1 Antibodies and Their Use
5/1/2005E-351-2004/0 Antibodies to Rheb, a Ras-Related Protein
5/1/2005E-245-2004/0 Methods of Reducing the Activity and Concentration of an Eph Receptor Tyrosine Kinase
4/1/2005E-265-1994/0
E-265-1994/1
Nucleotide and Deduced Amino Acid Sequences of a New Tumor Gene, Int6
4/1/2005E-324-2001/2 8,283,122Selections of Genes and Methods of Using the Same for Diagnosis and for Targeting the Therapy of Select Cancers
4/1/2005E-156-2004/0 Chinese Hamster Ovary Cells Resistant to Colcemid with Altered beta-Tubulin
3/1/2005E-105-2004/0
E-105-2004/1
Minimally Immunogenic Germline Sequence Variants of COL-1 Antibody and Their Use
3/1/2005E-166-2001/0 7,557,196HGC-1, A Gene Encoding a Member of the Olfactomedin-Related Protein Family
3/1/2005E-108-2004/0
E-234-2003/0
7,711,492Methods for Identifying, Diagnosing, and Predicting Survival of Lymphomas
1/1/2005E-017-2005/0 Methods and Composition for Development of Preclinical Testing of Anticancer Therapies Using Transgenic Animals
1/1/2005E-123-2001/0
E-124-2001/1
7,247,615Peptide Agonists of Prostate-Specific Antigen and Uses Thereof
9/1/2004E-243-2004/0 Vectors for Wild-Type DDR1b or DDR1b Mutant, and Production of THP-1 Cell Line Expressing Two DDR1 Isoforms, DDR1a and DDR1b
8/1/2004E-266-2004/0 Mouse Model of PRKAR1A Down-Regulation
6/1/2004E-112-1994/0 5,652,223
5,981,712
6,790,936
DNA Encoding CAI Resistance Proteins and Uses Thereof
5/1/2004E-131-2004/0 AT8, a Hybridoma Cell Line Producing a Monoclonal Antibody (MAb) Specific for Ly49G, a Mouse Natural Killer (NK) Cell Receptor
3/1/2004E-107-2004/0 Specific Antibodies to the Lymphatic Endothelial Cell Specific Hyaluronic Acid Receptor, LYVE-1
11/1/2003E-008-2001/0 7,598,077Compositions and Methods for Enhancing Differential Gene Expression
6/1/2003E-091-2002/0 7,329,502
7,981,610
Zap70 Protein Expression as a Marker for Chronic Lymphocytic Leukemia (CLL)
5/1/2003E-161-2003/0 Flp-in T-Rex Jurkat Cell Line
2/1/2003E-340-2002/0 4G10, a Monoclonal Antibody Against the Chemokine Receptor CXCR4, Raised Against a Synthetic Peptide of 38 Residues in Length Derived from the N-terminal Sequence of CXCR4
4/1/2002E-099-2001/0 Mitochondrial Topoisomerase I
11/1/2001E-261-1998/0 6,969,614Methods and Devices for Isolation and Analysis of Cellular Protein Content
5/1/2001E-203-1994/0 5,693,779Production and Use of Anti-Dorsalizing Morphogenetic Protein
4/1/2001E-149-2000/0 6,756,215Biologically Active FLAG-Epitope-Tagged Transforming Growth Factor Beta (TGF-beta) Protein
3/1/2001E-336-1987/1 5,693,778ARG, A Human Gene Related to but Distinct from ABL Proto-Oncogene
12/1/2000E-014-2000/0 6,600,018
7,223,853
7,947,651
8,158,603
Secreted Frizzled Related Protein, sFRP, Fragments and Methods of Use Thereof
9/1/2000E-142-1999/0 6,362,317
6,884,873
Anti-H2A Antibody and Method for Detecting DNA Double-Stranded Breaks
7/1/1999E-077-1999/0 6,623,960
7,524,939
Monoclonal Antibodies Specific And Inhibitory To Human Cytochrome P450 2C8, 2C9, 2C18 And 2C19 - New Avenues For Drug Discovery
6/1/1999E-032-1995/0 5,650,627Sensitive Assay for Measuring Gallium Levels in Body Tissues and Fluids
4/1/1999E-157-1994/1 6,787,306
7,402,387
Method and Composition for Detecting Dihydropyrimidine Dehydrogenase Splicing Mutations
3/1/1999E-071-1991/2 5,645,988Method of Identifying and Using Drugs with Selective Effect Against Cancer Cells
10/1/1998E-150-1998/0 6,323,325Agents That Bind To And Inhibit Cytochrome P450 2A6
10/1/1998E-122-1998/0 6,335,428Agents That Bind To And Inhibit Human Cytochrome P450 1A2
10/1/1997E-246-1988/0 Laminin A Peptides
5/1/1997E-046-1997/0 6,060,253Agents That Bind To And Inhibit Human Cytochrome P450 2D6
1/1/1997E-160-1992/1 5,717,067eps15, Substrate For The Epidermal Growth Factor Receptor Kinase
11/1/1996E-185-1995/0 5,939,530Inhibitory And Non-Inhibitory Antigen Binding Polypeptides Against Human P450 Enzymes
7/1/1996E-221-1989/0
E-221-1989/1
5,820,859
5,916,755
Novel Epidermal Growth Factor Receptor (ErbB-3) And Antibodies
4/1/1996E-029-1990/0
E-029-1990/1
5,702,907
5,811,262
Hepatocellular Carcinoma Oncogene
11/1/1994E-005-1993/0 5,532,348E6-Associated Protein And Methods Of Use
4/1/1994E-116-1992/0 5,569,602The First Immortalized Kaposi's Sarcoma Cell Line
1/1/1994E-253-1993/0 5,709,996
5,716,620
5,744,142
5,756,284
5,871,998
5,985,610
Self-Assembling Recombinant Papillomavirus Capsid Proteins
2/1/1992E-193-1990/0 Molecular Encapsulation and Delivery of Alkanes to Living Mammalian Cells for Risk Assessment and Pharmaceutical Applications
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