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Hot Research Paper Archives

2013

January's Featured Paper!

Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products

Neuropsychopharmacology advance online publication, 17 October 2012; doi:10.1038/npp.2012.204

Michael H Baumann, John S Partilla, Kurt R Lehner, Eric B Thorndike Alexander F Hoffman, Marion Holy, Richard B Rothman, Steven R Goldberg, Carl R Lupica, Harald H Sitte, Simon D Brandt, Srihari R Tella, Nicholas V Cozzi, Charles W Schindler

You can read more about this paper at the website for Neuropsychopharmacology.

February's Featured Paper!

PIncreased vulnerability to cocaine in mice lacking dopamine D3 receptors

PNAS Published online before print, October 8, 2012, doi:10.1073/pnas.1205297109

Rui Songa, Hai-Ying Zhang, Xia Li, Guo-Hua Bi, Eliot L. Gardner, and Zheng-Xiong Xi

You can read more about this paper at the website for PNAS.

2012

January's Featured Paper!

The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue

Neuropsychopharmacology 14 December 2011; doi: 10.1038/npp.2011.304

Michael H Baumann, Mario A Ayestas Jr, John S Partilla, Jacqueline R Sink, Alexander T Shulgin, Paul F Daley, Simon D Brandt, Richard B Rothman, Arnold E Ruoho, and Nicholas V Cozzi

You can read more about this paper at the website for Neuropsychophamacology.

February's Featured Paper!

Basolateral Amygdala-Driven Augmentation of Medial Prefrontal Cortex GABAergic Neurotransmission in Response to Environmental Stimuli Associated with Cocaine Administration

Neuropsychopharmacology 1 June 2011; 36, 2018 2029; doi:10.1038/npp.2011.89

Vladimir I Chefer, Ruizhong Wang, and Toni S Shippenberg

You can read more about this paper at the website for Neuropsychophamacology.

March's Featured Paper!

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

JPET November 2011 vol. 339 no. 2 662-677 | doi:10.1124/jpet.111.185025

Takato Hiranita, Paul L. Soto, Stephen J. Kohut, Theresa Kopajtic, Jianjing Cao, Amy H. Newman, Gianluigi Tanda, and Jonathan L. Katz

You can read more about this paper at the website for Journal of Pharmacology and Experimental Therapeutics.

April's Featured Paper!

Rat brains also have a default mode network

PNAS March 6, 2012 vol. 109 no. 10 3979-3984 | doi:10.1073/pnas.1200506109

Hanbing Lu, Qihong Zou, Hong Gu, Marcus E. Raichle, Elliot A. Stein, and Yihong Yang

You can read more about this paper at the website for the Proceedings for the National Academy of Sciences.

May's Featured Paper!

Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex

Nature Neuroscience 14, 1590–1597 (2011) doi:10.1038/nn.2957
Received 14 July 2011 | Accepted 15 September 2011 | Published online 30 October 2011

Yuji K Takahashi, Matthew R Roesch, Robert C Wilson, Kathy Toreson, Patricio O’Donnell, Yael Niv & Geoffrey Schoenbaum

You can read more about this paper at the website for the Nature Neuroscience.

June's Featured Paper!

Novel Use of a Lipid-Lowering Fibrate Medication to Prevent Nicotine Reward and Relapse: Preclinical Findings

Neuropsychopharmacology advance online publication, 28 March 2012; doi:10.1038/npp.2012.31

Leigh V Panlilio, Zuzana Justinova, Paola Mascia, Marco Pistis, Antonio Luchicchi, Salvatore Lecca, Chanel Barnes, Godfrey H Redhi, Jordan Adair, Stephen J Heishman, Sevil Yasar, Mano Aliczki, Jozsef Haller, and Steven R Goldberg

You can read more about this paper at the website for the Neuropsychopharmacology.

July's Featured Paper!

Role of Projections from Ventral Medial Prefrontal Cortex to Nucleus Accumbens Shell in Context-Induced Reinstatement of Heroin Seeking

J. Neurosci April 4, 2012 | 32(14):4982– 4991

Jennifer M. Bossert, Anna L. Stern, Florence R. M. Theberge, Nathan J. Marchant, Hui-Ling Wang, Marisela Morales, and Yavin Shaham

You can read more about this paper at the website for the The Journal of Neuroscience.

August's Featured Paper!

Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/ Hypoacetylation in the Rat Nucleus Accumbens

PLoS ONE 7(3): e34236. doi:10.1371/journal.pone.0034236

Tracey A. Martin, Subramaniam Jayanthi, Michael T. McCoy, Christie Brannock, Bruce Ladenheim, Tiffany Garrett, Elin Lehrmann, Kevin G. Becker, Jean Lud Cadet

You can read more about this paper at the website for the The Public Library of Science.

September's Featured Paper!

Medial Prefrontal Cortex Neuronal Activation and Synaptic Alterations after Stress-Induced Reinstatement of Palatable Food Seeking: A Study Using c-fos-GFP Transgenic Female Rats

J. Neurosci, June 20, 2012 • 32(25):8480–8490

Carlo Cifani, Eisuke Koya, Brittany M. Navarre, Donna J. Calu, Michael H. Baumann, Nathan J. Marchant, Qing-Rong Liu, Thi Khuc, James Pickel, Carl R. Lupica, Yavin Shaham, and Bruce T. Hope

You can read more about this paper at the website for the Journal of Neuroscience.

October's Featured Paper!

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

J. Med. Chem., 2012, 55 (15), pp 6689–6699 | DOI: 10.1021/jm300482h

Amy Hauck Newman, Thijs Beuming, Ashwini K. Banala, Prashant Donthamsetti, Katherine Pongetti, Alex LaBounty, Benjamin Levy, Jianjing Cao, Mayako Michino, Robert R. Luedtke, Jonathan A. Javitch, and Lei Shi

You can read more about this paper at the website for the Journal of Medicinal Chemistry.

November's Featured Paper!

Antagonism of Sigma-1 Receptors Blocks Compulsive-Like Eating

Neuropsychopharmacology, 2012 Nov;37(12):2593-604. doi: 10.1038/npp.2012.89

Pietro Cottone, Xiaofan Wang, Jin Won Park, Marta Valenza, Angelo Blasio, Jina Kwak, Malliga R Iyer, Luca Steardo, Kenner C Rice, Teruo Hayashi, and Valentina Sabino

You can read more about this paper at the website for Neuropsychopharmacology.

December's Featured Paper!

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Biol. Psych., 2012;72:405–413

Claus J. Loland, Maddalena Mereu, Oluyomi M. Okunola, Jianjing Cao, Thomas E. Prisinzano, Sonia Mazier, Theresa Kopajtic, Lei Shi, Jonathan L. Katz, Gianluigi Tanda, Amy Hauck Newman

You can read more about this paper at the website for Science Direct.

2011

January's Hot Paper!

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Science 330, 1091 (2010); DOI: 10.1126/science.1197410

Ellen Y. T. Chien, Wei Liu, Qiang Zhao, Vsevolod Katritch, Gye Won Han, Michael A. Hanson, Lei Shi, Amy Hauck Newman, Jonathan A. Javitch, Vadim Cherezov, Raymond C. Stevens

You can read more about this paper at the website for the journal Science.

February's Hot Paper!

Shift from Goal-Directed to Habitual Cocaine Seeking after Prolonged Experience in Rats

J Neurosci., November 17, 2010 • 30(46):15457–15463

Agustin Zapata, Vicki L. Minney, and Toni S. Shippenberg

You can read more about this paper at the website for The Journal of Neuroscience.

March's Hot Paper!

NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization

PLoS ONE 5(8): e12141. doi:10.1371

Yu Luo, Cameron H. Good, Oscar Diaz-Ruiz, YaJun Zhang, Alexander F. Hoffman, Lufei Shan, Serena Y. Kuang, Nasir Malik, Vladimir I. Chefer, Andreas C. Tomac, Carl R. Lupica, Cristina M.
Bäckman

You can read more about this paper at the website for The Public Library of Science.

April's Hot Paper!

Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

PNAS October 26, 2010 vol. 107 no. 43 18676-18681

Gemma Navarro, Estefanía Moreno, Marisol Aymerich, Daniel Marcellino, Peter J. McCormick, Josefa Mallol, Antoni Cortés, Vicent Casadó, Enric I. Canela, Jordi Ortiz, Kjell Fuxe, Carmen Lluís, Sergi Ferré, and Rafael Franco

You can read more about this paper at the website for the Proceedings of the National Academy of Sciences.

May's Hot Paper!

Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin

Nature Neuroscience 14, 420–422 (2011)

Jennifer M Bossert, Anna L Stern, Florence R M Theberge, Carlo Cifani, Eisuke Koya, Bruce T Hope & Yavin Shaham

You can read more about this paper at the website for the journal Nature Neuroscience.

June's Hot Paper!

Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by
resting-state functional connectivity

NeuroImage 53 (2010) 593–601

Hong Gu, Betty Jo Salmeron, Thomas J. Ross, Xiujuan Geng, Wang Zhan, Elliot A. Stein, Yihong Yang

You can read more about this paper at the website for the journal NeuroImage.

July's Hot Paper!

Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors

BIOL PSYCHIATRY 2011;69:633–641

Paola Mascia, Marco Pistis, Zuzana Justinova, Leigh V. Panlilio, Antonio Luchicchi, Salvatore Lecca, Maria Scherma, Walter Fratta, Paola Fadda, Chanel Barnes, Godfrey H. Redhi, Sevil Yasar, Bernard Le Foll, Gianluigi Tanda, Daniele Piomelli, and Steven R. Goldberg

You can read more about this paper at the website for the journal Biological Psychiatry.

August's Hot Paper!

Molecular Microscopy of Brain Gangliosides: Illustrating their Distribution in Hippocampal Cell Layers

ACS Chem. Neurosci., 2011, 2 (4), pp 213–222

Benoit Colsch, Shelley N. Jackson, Sucharita Dutta and Amina S. Woods

You can read more about this paper at the website for the journal ACS Chemical Neuroscience.

September's Featured Paper!

FACS Identifies Unique Cocaine-Induced Gene Regulation in Selectively Activated Adult Striatal Neurons

The Journal of Neuroscience, 16 March 2011, 31(11): 4251-4259

Danielle Guez-Barber, Sanya Fanous, Sam A. Golden, Regina Schrama, Eisuke Koya, Anna L. Stern, Jennifer M. Bossert, Brandon K. Harvey, Marina R. Picciotto, Bruce T. Hope

You can read more about this paper at the website for The Journal of Neuroscience.

October's Featured Paper!

Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

Nature Chemical Biology, 3 April 2011, 7: 296–303 (2011)

Wei Xiong, KeJun Cheng, Tanxing Cui, Grzegorz Godlewski, Kenner C Rice, Yan Xu & Li Zhang

You can read more about this paper at the website for Chemical Biology.

November's Featured Paper!

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

Nature Molecular Psychiatry, 12 July 2011; doi: 10.1038/mp.2011.82

J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis, and R B Innis

You can read more about this paper at the website for Molecular Psychiatry.

December's Featured Paper!

Mesocorticolimbic Glutamatergic Pathway

JNEUROSCI, 8 June 2011, 31(23): 8476-8490; doi: 10.1523

Tsuyoshi Yamaguchi, Hui-Ling Wang, Xueping Li, Tsz H. Ng, and Marisela Morales

You can read more about this paper at the website for The Journal of Neuroscience.

2010

January's Hot Paper!

Targeted Disruption of Cocaine-activated Nucleus Accumbens Neurons Prevents Context-specific Sensitization

Nature Neuroscience 12, 1069 -1073 (2009)

Eisuke Koya, Sam A Golden, Brandon K Harvey, Danielle H Guez-Barber, Alexander Berkow, Danielle E Simmons, Jennifer M Bossert, Sunila G Nair, Jamie L Uejima, Marcelo T Marin, Timothy B Mitchell, David Farquhar, Sukhen C Ghosh, Brandi J Mattson & Bruce T Hope

You can read more about this paper at the website of the journal Nature Neuroscience.

February's Hot Paper!

Association of Nicotine Addiction and Nicotine’s Actions With Separate Cingulate Cortex Functional Circuits

Arch Gen Psychiatry. 2009;66(4):431-441

L. Elliot Hong, MD; Hong Gu, PhD; Yihong Yang, PhD; Thomas J. Ross, PhD; Betty Jo Salmeron, MD; Brittany Buchholz, BS; Gunvant K. Thaker, MD; Elliot A. Stein, PhD (pictured on right)

You can read more about this paper at the website for the Archives of General Psychiatry.

March's Hot Paper!

Role of Ventral Tegmental Area Glial Cell Line–Derived Neurotrophic Factor in Incubation of Cocaine Craving

BIOL PSYCHIATRY 2009;66:137–145

Lin Lu, Xi Wang, Ping Wu, Chunmei Xu, Mei Zhao, Marisela Morales, Brandon K. Harvey, Barry J. Hoffer, and Yavin Shaham

You can read more about this paper at the website for the Journal of the Society of Biological Psychiatry.

April's Hot Paper!

Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A1 Receptors

The Journal of Neuroscience, January 13, 2010, 30(2):545-555

Alexander F. Hoffman, Nora Laaris, Masahito Kawamura, Susan A. Masino, and Carl R. Lupica

You can read more about this paper at the website for the Journal of Neuroscience.

May's Hot Paper!

Nogo Receptor 1 Regulates Formation of Lasting Memories

PNAS, December 1, 2009 vol. 106 no. 48 20476-20481

Alexandra Karlén, Tobias E. Karlsson, Anna Mattsson, Karin Lundströmer, Simone Codeluppi, Therese M. Pham, Cristina M. Bäckman, Sven Ove Ögrena, Elin Åberg, Alexander F. Hoffman, Michael A. Sherling, Carl R. Lupica, Barry J. Hoffer, Christian Spenger, Anna Josephson, Stefan Brené, and Lars Olson

You can read more about this paper at the website for the Proceedings of the National Academy of Sciences.

June's Hot Paper!

Tobacco, Cocaine, and Heroin: Craving and Use During Daily Life

Addictive Behaviors 35 (2010) 318–324

David H. Epstein, Gina F. Marrone, Stephen J. Heishman, John Schmittner, Kenzie L. Preston

You can read more about this paper at the website for Addictive Behaviors.

July's Hot Paper!

Reinforcing Effects of σ-Receptor Agonists in Rats Trained to Self-Administer Cocaine

J Pharmacol Exp Ther. 2010 Feb;332(2):515-24. Epub 2009 Nov 5.

Takato Hiranita, Paul L. Soto, Gianluigi Tanda, and Jonathan L. Katz

You can read more about this paper at the website for The Journal of Pharmacology and Experimental Theraputics.

August's Hot Paper!

Effects of Early-Life Stress on Serotonin1A Receptors in Juvenile Rhesus Monkeys Measured by Positron Emission Tomography

Biological Psychiatry Volume 67, Issue 12,1115-1280

Simona Spinelli, Svetlana Chefer, Richard E. Carson, Elaine Jagoda, Lixin Lang, Markus Heilig, Christina S. Barr, Stephen J. Suomi, J. Dee Higley, and Elliot A. Stein

You can read more about this paper at the website for Biological Psychiatry.

September's Hot Paper!

A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

PNAS July 27, 2010 vol. 107 no. 30 13509-13514

L. Elliot Hong, Colin A. Hodgkinson, Yihong Yang, Hemalatha Sampath, Thomas J. Ross, Brittany Buchholz, Betty Jo Salmeron, Vibhuti Srivastava, Gunvant K. Thaker, David Goldman, and Elliot A. Stein

You can read more about this paper at the website for the Proceedings of the National Academy of Sciences.

October's Hot Paper!

Real-time, spatially resolved analysis of serotonin transporter activity and regulation using the fluorescent substrate, ASP+

J. Neurochem. (2010) 114, 1019–1029

Murat Oz, Therissa Libby, Bronwyn Kivell, Vanaja Jaligam, Sammanda Ramamoorthy, Toni S. Shippenberg

You can read more about this paper at the website for the Journal of Neurochemistry.

November's Hot Paper!

Glutamatergic and Nonglutamatergic Neurons of the Ventral Tegmental Area Establish Local Synaptic Contacts with Dopaminergic and Nondopaminergic Neurons

J. Neurosci., January 6, 2010 • 30(1):218 –229

Alice Dobi, Elyssa B. Margolis, Hui-Ling Wang, Brandon K. Harvey, and Marisela Morales

You can read more about this paper at the website for The Journal of Neuroscience.

December's Hot Paper!

Afferent-Specific AMPA Receptor Subunit Composition and Regulation of Synaptic Plasticity in Midbrain Dopamine Neurons by Abused Drugs

J Neurosci., June 9, 2010 • 30(23):7900 –7909

Cameron H. Good and Carl R. Lupica

You can read more about this paper at the website for The Journal of Neuroscience.

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